CD147 immunoglobulin superfamily receptor function and role in pathology

被引：254

作者：

Iacono, Kathryn T. ^{[1
]}

Brown, Amy L. ^{[1
]}

Greene, Mark I. ^{[1
]}

Saouaf, Sandra J. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2007年 / 83卷 / 03期

关键词：

CD147; EMMPRIN; MMP; MCT; immunoglobulin superfamily; integrin; tumor; metastasis;

D O I：

10.1016/j.yexmp.2007.08.014

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：283 / 295

页数：13

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