Specific Removal of C-Reactive Protein by Apheresis in a Porcine Cardiac Infarction Model

被引：28

作者：

Slagman, Anna Christine ^{[1
]}

Bock, Christopher ^{[2
]}

Abdel-Aty, Hassan ^{[5
]}

Vogt, Birgit ^{[2
]}

Gebauer, Frank ^{[2
]}

Janelt, Gunnar ^{[2
]}

Wohlgemuth, Franziska ^{[2
]}

Morgenstern, Rene ^{[2
]}

Yapici, Guelcan ^{[2
]}

Puppe, Astrid ^{[2
]}

Modersohn, Diethelm ^{[1
]}

Mans, Doerte ^{[1
]}

Jerichow, Timo ^{[1
]}

Ott, Sascha ^{[4
]}

Kunze, Rudolf ^{[6
]}

Schroedl, Wieland ^{[7
]}

Janko, Christina ^{[8
]}

Hermann, Martin ^{[8
]}

Kalden, Joachim R. ^{[8
]}

Kern, Peter ^{[10
]}

Parsch, Hans ^{[9
]}

Kirschfink, Michael ^{[11
]}

Schulz-Menger, Jeanette ^{[5
]}

Roettgen, Rainer ^{[3
]}

Unger, Juliane K. ^{[4
]}

Frei, Ulrich ^{[2
]}

Schindler, Ralf ^{[2
]}

Moeckel, Martin ^{[1
]}

Sheriff, Ahmed ^{[2
]}

机构：

[1] Charite, Emergency Med Unit, Dept Cardiol, Berlin, Germany

[2] Charite, Dept Nephrol & Internal Intens Care Med, Berlin, Germany

[3] Charite, Dept Radiol, Berlin, Germany

[4] Charite, Dept Anim Care, Berlin, Germany

[5] Helios Clin Berlin Buch, Charite Berlin, Franz Volhard Klin, Cardiac MRI Team, Berlin, Germany

[6] Off Campus Max Delbruck Ctr, Berlin, Germany

[7] Univ Leipzig, Inst Bacteriol & Mycol, Leipzig, Germany

[8] Univ Hosp Erlangen, Dept Internal Med 3, Inst Clin Immunol & Rheumatol, Erlangen, Germany

[9] Univ Hosp Erlangen, Cent Lab, Erlangen, Germany

[10] Capio Franz von Prummer Klin, Bad Bruckenau, Germany

[11] Heidelberg Univ, Dept Immunol, Heidelberg, Germany

来源：

BLOOD PURIFICATION | 2011年 / 31卷 / 1-3期

关键词：

Acute myocardial infarction; Acute phase protein; Adsorber; Apheresis; C-reactive protein; ACUTE MYOCARDIAL-INFARCTION; COMPLEMENT; DISEASE; DAMAGE; SIZE;

D O I：

10.1159/000320763

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction. Methods: We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction. Results: We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by similar to 70% in the established treatment system. Conclusion: We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：9 / 17

页数：9

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