Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone

被引：37

作者：

Barrero, Alejandro F. ^{[1
]}

Mar Herrador, M. ^{[1
]}

Quilez del Moral, Jose F. ^{[1
]}

Arteaga, Pilar ^{[1
]}

Meine, Niklas ^{[1
]}

Carmen Perez-Morales, M. ^{[1
]}

Catalan, Julieta V. ^{[1
]}

机构：

[1] Univ Granada, Dept Organ Chem, Inst Biotechnol, E-18071 Granada, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 04期

关键词：

ESSENTIAL OILS; REARRANGEMENT; PHOTOCHEMISTRY; DERIVATIVES; ALKYLATION; TERPENOIDS;

D O I：

10.1039/c0ob00467g

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Highly efficient preparations of anticancer beta-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3-5 steps with excellent overall yields (43-54%). An enantioselective approach to these molecules is also described

引用

页码：1118 / 1125

页数：8

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