Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients

被引：36

作者：

Hiltunen, M

Mannermaa, A

Helisalmi, S

Koivisto, A

Lehtovirta, M

Ryynänen, M

Riekkinen, P

Soininen, H

机构：

[1] Kuopio Univ Hosp, Dept Neurol, Kuopio 70211, Finland

[2] Univ Kuopio, Kuopio 70211, Finland

[3] Kuopio Univ Hosp, Div Diagnost Serv, Chromosome & DNA Lab, Kuopio 70211, Finland

[4] Kuopio Univ Hosp, Dept Obstet & Gynaecol, Clin Genet Unit, Kuopio 70211, Finland

[5] Univ Kuopio, Dept Neurosci, AI Virtanen Inst, FIN-70211 Kuopio, Finland

来源：

NEUROSCIENCE LETTERS | 1998年 / 250卷 / 01期

基金：

芬兰科学院;

关键词：

Alzheimer's disease; apolipoprotein E4 allele; butyrylcholinesterase K variant; chromosome; 3; genetics; linkage disequilibrium;

D O I：

10.1016/S0304-3940(98)00453-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Examination of the allelic frequency of the butyrylcholinesterase K (BChE-K) variant gene revealed no increase among Finnish late-onset Alzheimer's disease (AD) patients either as a whole or among a subset of AD patients carrying the epsilon 4 allele of apolipoprotein E (ApoE4). In contrast, BChE-K allele frequency was significantly reduced in the Finnish AD patient group under 75 years of age carrying the ApoE4 allele when compared to the non-demented controls (chi(2), P < 0.05). The proportion of subjects with both BChE-K and ApoE4 alleles was 14% and 41% in AD and control groups, respectively (chi(2), P < 0.01; odds-ratio 0.22, 95% CI 0.07-0.71). These results are in contrast to a previous study on English AD patients, in which the genes for BChE-K and ApoE4 were suggested to act in synergy. (C) 1998 Elsevier Science Ireland Ltd. AII rights reserved.

引用

页码：69 / 71

页数：3

共 19 条

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