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Evaluation of a novel vaginal bromocriptine mesylate formulation: a pilot study

被引：8
作者：
Darwish, AM
Hafez, E
El-Gebali, L
Hassan, SB
机构：
[1] Assiut Univ, Dept Obstet & Gynaecol, Fac Med, Assiut, Egypt
[2] Assiut Univ, Dept Pharmaceut, Fac Pharm, Infertil Outpatient Clin,Mother Hlth Hosp, Assiut, Egypt
来源：
FERTILITY AND STERILITY | 2005年 / 83卷 / 04期
关键词：
D O I：
10.1016/j.fertnstert.2004.09.024
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Because of the frequent side effects found with oral bromocriptine, we created two formulas of vaginal bromocriptine suppositories to compare with vaginal application of bromocriptine tablets. The formula containing, brornocriptine and a releasing agent (Pluronic F127) showed tin increased dissolution rate, 39-fold greater than that of the pure drug alone, and subsequently was effective in lowering serum prolactin. (c) 2005 by American Society for Reproductive Medicine.
引用
收藏
页码：1053 / 1055
页数：3
相关论文
共 8 条
[1]   VAGINAL BROMOCRIPTINE - CLINICAL AND BIOCHEMICAL EFFECTS [J].
GINSBURG, J ;
HARDIMAN, P ;
THOMAS, M .
GYNECOLOGICAL ENDOCRINOLOGY, 1992, 6 (02) :119-126
[2]   Vaginal bromocriptine in hyperprolactinemic patients and puerperal women [J].
Jasonni, Valerio Maria ;
Raffelli, Roberta ;
de March, Adelina ;
Frank, Giorgio ;
Flamigni, Carlo .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1991, 70 (06) :493-495
[3]  
KATZ E, 1991, FERTIL STERIL, V55, P882
[4]  
KATZ E, 1989, OBSTET GYNECOL, V73, P517
[5]  
KLETZKY OA, 1989, FERTIL STERIL, V51, P269
[6]   ORAL AND INJECTABLE LONG-LASTING BROMOCRIPTINE PREPARATIONS IN HYPERPROLACTINEMIA - COMPARISON OF THEIR PROLACTIN LOWERING ACTIVITY, TOLERABILITY AND SAFETY [J].
MEROLA, B ;
COLAO, A ;
CARUSO, E ;
SARNACCHIARO, F ;
BRIGANTI, F ;
LANCRANJAN, I ;
LOMBARDI, G ;
SCHETTINI, G .
GYNECOLOGICAL ENDOCRINOLOGY, 1991, 5 (04) :267-276
[7]   Vaginal cabergoline in the treatment of hyperprolactinemic patients intolerant to oral dopaminergics [J].
Motta, T ;
deVincentiis, S ;
Marchini, M ;
Colombo, N ;
DAlberton, A .
FERTILITY AND STERILITY, 1996, 65 (02) :440-442
[8]   Enhancement of dissolution of ethopropazine using solid dispersions prepared with phospholipid and/or polyethylene glycol [J].
Prabhu, S ;
Brocks, DR ;
Betageri, GV .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2001, 27 (05) :413-418
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