Regulation of JAK-STAT signalling in the immune system

被引：1100

作者：

Shuai, K ^{[1
]}

Liu, B

机构：

[1] Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 11期

关键词：

D O I：

10.1038/nri1226

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cytokine-activated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. Dysregulation of JAK-STAT signalling is associated with various immune disorders. The signalling strength, kinetics and specificity of the JAK-STAT pathway are modulated at many levels by distinct regulatory proteins. Here, we review recent studies on the regulation of the JAK-STAT pathway that will enhance our ability to design rational therapeutic strategies for immune diseases.

引用

页码：900 / 911

页数：12

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