The neutrophil: Function and regulation in innate and humoral immunity

被引:203
作者
Burg, ND
Pillinger, MH
机构
[1] Hosp Joint Dis & Med Ctr, Dept Rheumatol, New York, NY 10003 USA
[2] NYU, Sch Med, Dept Med, New York, NY 10016 USA
[3] Manhattan VA Hosp, New York Harbor Hlth Care Syst, Dept Med, New York, NY 10010 USA
关键词
neutrophil; adhesion; NADPH oxidase; granules; phagocytosis; chemoattractant;
D O I
10.1006/clim.2001.5007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The neutrophil is a critical effector cell in humoral and innate immunity and plays vital roles in phagocytosis and bacterial killing. Discussed here are the neutrophil components necessary for these processes and the diseases in which these components are either lacking or dysfunctional, illustrating that normal neutrophil function is vital for health. (C) 2001 Academic Press.
引用
收藏
页码:7 / 17
页数:11
相关论文
共 127 条
[1]   CYCLIC AMP-INCREASING AGENTS INTERFERE WITH CHEMOATTRACTANT INDUCED RESPIRATORY BURST IN NEUTROPHILS AS A RESULT OF THE INHIBITION OF PHOSPHATIDYLINOSITOL 3-KINASE RATHER THAN RECEPTOR-OPERATED CA2+ INFLUX [J].
AHMED, MU ;
HAZEKI, K ;
HAZEKI, O ;
KATADA, T ;
UI, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (40) :23816-23822
[2]   Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation [J].
Ambruso, DR ;
Knall, C ;
Abell, AN ;
Panepinto, J ;
Kurkchubasche, A ;
Thurman, G ;
Gonzalez-Aller, C ;
Hiester, A ;
deBoer, M ;
Harbeck, RJ ;
Oyer, R ;
Johnson, GL ;
Roos, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4654-4659
[3]   ARRANGEMENT OF THE RESPIRATORY BURST OXIDASE IN THE PLASMA-MEMBRANE OF THE NEUTROPHIL [J].
BABIOR, GL ;
ROSIN, RE ;
MCMURRICH, BJ ;
PETERS, WA ;
BABIOR, BM .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (06) :1724-1728
[4]   Identification of the homologous beige and Chediak-Higashi syndrome genes [J].
Barbosa, MDFS ;
Nguyen, QA ;
Tchernev, VT ;
Ashley, JA ;
Detter, JC ;
Blaydes, SM ;
Brandt, SJ ;
Chotai, D ;
Hodgman, C ;
Solari, RCE ;
Lovett, M ;
Kingsmore, SF .
NATURE, 1996, 382 (6588) :262-265
[5]   Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis [J].
Belaaouaj, A ;
McCarthy, R ;
Baumann, M ;
Gao, ZM ;
Ley, TJ ;
Abraham, SN ;
Shapiro, SD .
NATURE MEDICINE, 1998, 4 (05) :615-618
[6]   Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase [J].
Belaaouaj, AA ;
Kim, KS ;
Shapiro, SD .
SCIENCE, 2000, 289 (5482) :1185-1187
[7]   CHEMOATTRACTANT SIGNALING AND LEUKOCYTE ACTIVATION [J].
BOKOCH, GM .
BLOOD, 1995, 86 (05) :1649-1660
[8]   Granules of the human neutrophilic polymorphonuclear leukocyte [J].
Borregaard, N ;
Cowland, JB .
BLOOD, 1997, 89 (10) :3503-3521
[9]   Bioactive proteinase 3 on the cell surface of human neutrophils: Quantification, catalytic activity, and susceptibility to inhibition [J].
Campbell, EJ ;
Campbell, MA ;
Owen, CA .
JOURNAL OF IMMUNOLOGY, 2000, 165 (06) :3366-3374
[10]   Integrin-dependent homotypic adhesion of neutrophils - Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase-dependent pathway [J].
Capodici, C ;
Pillinger, MH ;
Han, G ;
Philips, MR ;
Weissmann, G .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (01) :165-175