The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?

被引：103

作者：

Taddei, A

Roche, D

Bickmore, WA

Almouzni, G

机构：

[1] Inst Curie, Res Sect, CNRS, UMR 218, F-75248 Paris 05, France

[2] MRC, Human Genet Unit, Edinburgh, Midlothian, Scotland

来源：

EMBO REPORTS | 2005年 / 6卷 / 06期

关键词：

chromatin; histone deacetylase inhibitors; nuclear organization; pericentric heterochromatin; anticancer therapy;

D O I：

10.1038/sj.embor.7400441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone acetylation regulates many chromosome functions, such as gene expression and chromosome segregation. Histone deacetylase inhibitors (HDACIs) induce growth arrest, differentiation and apoptosis of cancer cells ex vivo, as well as in vivo in tumour-bearing animal models, and are now undergoing clinical trials as anti-tumour agents. However, little attention has been paid to how HDACIs function in these biological settings and why different cells respond in different ways. Here, we discuss the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.

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收藏

页码：520 / 524

页数：5

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