Doparnine receptor-interacting proteins:: the Ca2+ connection in dopamine signaling

被引:134
作者
Bergson, C [1 ]
Levenson, R
Goldman-Rakic, PS
Lidow, MS
机构
[1] Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA
[2] Penn State Coll Med, Dept Pharmacol, Hershey, PA 17033 USA
[3] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA
[4] Univ Maryland, Dept Biomed Sci, Sch Med, Baltimore, MD 21201 USA
关键词
D O I
10.1016/S0165-6147(03)00232-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca2+ sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca2+ homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.
引用
收藏
页码:486 / 492
页数:7
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