Effects of ethylene glycol-based graft, star-shaped, and dendritic polymers on solubilization and controlled release of paclitaxel

被引：136

作者：

Ooya, T

Lee, J

Park, K ^{[1
]}

机构：

[1] Purdue Univ, Sch Pharm, Dept Pharmaceut, W Lafayette, IN 47907 USA

[2] Japan Adv Inst Sci & Technol, Sch Mat Sci, Tatsunokuchi, Ishikawa 9231292, Japan

[3] Purdue Univ, Sch Pharm, Dept Biomed Engn, W Lafayette, IN 47907 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2003年 / 93卷 / 02期

关键词：

poly(ethylene glycol); star polymer; dendrimer; paclitaxel; solubilization; RADICAL POLYMERIZATION; DELIVERY;

D O I：

10.1016/j.jconrel.2003.07.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New methods and pharmaceutical compositions were developed to increase the aqueous solubility of paclitaxel (PTX), a poorly water-soluble drug. Graft and star-shaped graft polymers consisting of poly(ethylene glycol) (PEG400) graft chains increased the PTX solubility in water by three orders of magnitude. Polyglycerol dendrimers (dendriPGs) dissolved in water at high concentrations without significantly increasing the viscosity and, at 80 wt.%, were found to increase the solubility of PTX 10,000-fold. The solubilized PTX was released from graft polymers, star-shaped graft polymers, and the dendriPGs into the surrounding aqueous solution. The release rate was a function of the star shape and the dendrimer generation. The availability of the new graft, star and dendritic polymers having ethylene glycol units should permit development of novel delivery systems for other poorly water-soluble drugs. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：121 / 127

页数：7

共 12 条

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