Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question

被引：204

作者：

Neurath, MF ^{[1
]}

Finotto, S

Fuss, I

Boirivant, M

Galle, PR

Strober, W

机构：

[1] Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, D-55131 Mainz, Germany

[2] NIH, Mucosal Immun Sect, Bethesda, MD 20814 USA

[3] La Sapienza, Dept Immunol, I-35461 Rome, Italy

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 01期

关键词：

D O I：

10.1016/S1471-4906(00)01798-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.

引用

页码：21 / 26

页数：6

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