Immunoaffinity capillary electrophoresis applications of clinical and pharmaceutical relevance

The role of capillary electrophoresis (CE) in analytical procedures that yield accurate and precise information is discussed. The other mode of CE termed immunoaffiniy capillary electrophoresis (IACE) has been used as a promising technique to trap, enrich, clean, and analyze a variety of substances present in a cell, organelle, and biological fluid. The IACE performed with an instrument with multiple capillaries, each connected to an analyte concentrator within a device with a cruciform configuration, operate consistently for many runs, maintaining reproducible migration times and peak areas for the analyte study. Furthermore, the IACE instrument can perform on-line cleavage of proteins and other biological reactions.