The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever

被引：99

作者：

Calligaris, Lorenzo ^{[1
,2
]}

Marchetti, Federico ^{[1
,2
]}

Tommasini, Alberto ^{[1
,2
]}

Ventura, Alessandro ^{[1
,2
]}

机构：

[1] Childrens Hosp IRCCS Burlo Garofolo, Inst Child Hlth, Dept Pediat, I-34137 Trieste, Italy

[2] Univ Trieste, Dept Reprod & Dev Sci, Trieste, Italy

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2008年 / 167卷 / 06期

关键词：

familial Mediterranean fever; colchicine resistance; anakinra;

D O I：

10.1007/s00431-007-0547-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Colchicine is the treatment of choice in familial Mediterranean fever (FMF) for the prevention of both attacks and secondary amyloidosis. The overall nonresponder rate is about 5-10%. Anakinra is known to have good effectiveness in a severe autoinflammatory syndrome [chronic infantile neurological cutaneous and articular (CINCA) syndrome] and other recurrent hereditary periodic fevers. Pyrin-the protein involved in FMF-has a role in activating the proinflammatory cytokine interleukin (IL)-1 beta. We report the effectiveness of the addition of an IL-1-receptor inhibitor (anakinra) to colchicine in controlling the febrile attacks and acute phase response in an adolescent with FMF resistant to colchicine.

引用

页码：695 / 696

页数：2

共 6 条

[1] The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production
Chae, Jae Jin
Wood, Geryl
Masters, Seth L.
Richard, Katharina
Park, Grace
Smith, Brian J.
Kastner, Daniel L.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) : 9982 - 9987
[2] Neonatal-onset multisystem inflammatory disease responsive to interleukin-1β inhibition
Goldbach-Mansky, Raphaela
Dailey, Natalie J.
Canna, Scott W.
Gelabert, Ana
Jones, Janet
Rubin, Benjamin I.
Kim, H. Jeffrey
Brewer, Carmen
Zalewski, Christopher
Wiggs, Edythe
Hill, Suvimol
Turner, Maria L.
Karp, Barbara I.
Aksentijevich, Ivona
Pucino, Frank
Penzak, Scott R.
Haverkamp, Margje H.
Stein, Leonard
Adams, Barbara S.
Moore, Terry L.
Fuhlbrigge, Robert C.
Shaham, Bracha
Jarvis, James N.
O'Neil, Kathleen
Vehe, Richard K.
Beitz, Laurie O.
Gardner, Gregory
Hannan, William P.
Warren, Robert W.
Horn, William
Cole, Joe L.
Paul, Scott M.
Hawkins, Philip N.
Pham, Tuyet Hang
Snyder, Christopher
Wesley, Robert A.
Hoffmann, Steven C.
Holland, Steven M.
Butman, John A.
Kastner, Daniel L.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (06) : 581 - 592
[3] Colchicine use in children and adolescents with familial Mediterranean fever: Literature review and consensus statement
Kallinich, Tilmann
Haffner, Dieter
Niehues, Tim
Huss, Kristina
Lainka, Elke
Neudorf, Ulrich
Schaefer, Christof
Stojanov, Silvia
Timmann, Christian
Keitzer, Rolf
Ozdogan, Huri
Ozen, Seza
[J]. PEDIATRICS, 2007, 119 (02) : E474 - E483
[4] Diagnostics and therapeutic insights in a severe case of mevalonate kinase deficiency
Nevyjel, Marco
Pontillo, Alessandra
Calligaris, Lorenzo
Tommasini, Alberto
D'Osualdo, Andrea
Waterham, Hans R.
Granzotto, Marilena
Crovella, Sergio
Barbi, Egidio
Ventura, Alessandro
[J]. PEDIATRICS, 2007, 119 (02) : E523 - E527
[5] Familial mediterranean fever: revisiting an ancient disease
Ozen, S
[J]. EUROPEAN JOURNAL OF PEDIATRICS, 2003, 162 (7-8) : 449 - 454
[6] Seyahi E, 2006, CLIN EXP RHEUMATOL, V24, pS99

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