Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients

被引：35

作者：

Margiotti, K

Sangiuolo, F

De Luca, A

Froio, F

Pearce, CL

Ricci-Barbini, V

Micali, F

Bonafè, M

Franceschi, C

Dallapiccola, B

Novelli, G

Reichardt, JKV

机构：

[1] Univ Roma Tor Vergata, Dipartimento Biopatol & Diagnost Immagini, I-00133 Rome, Italy

[2] USC, Keck Sch Med, Dept Biochem & Mol Biol, Inst Med Genet, Los Angeles, CA USA

[3] Osped Villa San Pietro, Serv Patol Clin, Rome, Italy

[4] USC, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA USA

[5] Osped CSS, IRCCS, Div Urol, San Giovanni Rotondo, Italy

[6] Univ Bologna, Dipartimento Patol Sperimentale, I-40126 Bologna, Italy

[7] Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, Rome, Italy

[8] CSS Mendel Inst, Rome, Italy

来源：

DISEASE MARKERS | 2000年 / 16卷 / 3-4期

关键词：

prostate cancer; SRD5A2; gene; prostate cancer risk; polymorphic variant;

D O I：

10.1155/2000/683607

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA), dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89, We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.

引用

页码：147 / 150

页数：4

共 20 条

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