Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum

被引:64
作者
Hughes, AL [1 ]
Verra, F
机构
[1] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA
[2] Univ Roma La Sapienza, Ist Parassitol, I-00185 Rome, Italy
关键词
effective population size; genetic polymorphism; malaria; Plasmodium falciparum;
D O I
10.1098/rspb.2001.1759
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
It has been proposed that the virulent human malaria parasite Plasmodium falciparum underwent a recent severe population bottleneck. In order to test this hypothesis, we estimated the effective population size of this species from the patterns of nucleotide substitution at 23 nuclear protein-coding loci, using a variety of methods based on coalescent theory. Both simple methods and phylogenetically based maximum likelihood methods yielded the conclusion that the effective population size of this species has been of the order of at least 105 for the past 300 000-400 000 years.
引用
收藏
页码:1855 / 1860
页数:6
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