Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

被引：162

作者：

Conde, Javier ^{[1
]}

Scotece, Morena ^{[1
]}

Gomez, Rodolfo ^{[2
]}

Lopez, Veronica ^{[1
]}

Jesus Gomez-Reino, Juan ^{[1
]}

Lago, Francisca ^{[3
]}

Gualillo, Oreste ^{[1
]}

机构：

[1] Univ Santiago, NEIRID Lab NeuroEndocrine Interact Rheumatol & In, SERGAS, Clin Hosp,Inst Med Res IDIS, Santiago De Compostela, Spain

[2] Fdn Jimenez Diaz, Div Rheumatol, E-28040 Madrid, Spain

[3] Univ Santiago, Mol & Cellular Cardiol Lab, SERGAS, Clin Hosp, Santiago De Compostela, Spain

来源：

BIOFACTORS | 2011年 / 37卷 / 06期

关键词：

adipokines; inflammation; adipose tissue; GELATINASE-ASSOCIATED LIPOCALIN; COLONY-ENHANCING FACTOR; SYNTHASE TYPE-II; CHRONIC LIVER-DISEASE; KAPPA-B ACTIVATION; RHEUMATOID-ARTHRITIS; INSULIN-RESISTANCE; IN-VITRO; CORONARY ATHEROSCLEROSIS; ADIPONECTIN RECEPTORS;

D O I：

10.1002/biof.185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Until the identification of leptin, the first adipokine discovered in 1994, adipose tissue was considered only as an energy storage tissue. However, it is now clear that adipose tissue is an endocrine/paracrine/autocrine organ, which plays a relevant role in physiopathology of several inflammatory diseases. Actually, it is mainly involved not only in the low-grade inflammatory status in obesity but also in other relevant inflammatory conditions and autoimmune disorders. In this review article, we discuss the main biological activities of leptin, adiponectin, lipocalin-2, resistin, and visfatin, as well as their contributions to certain inflammatory conditions.

引用

页码：413 / 420

页数：8

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