DNA mismatch repair: Molecular mechanism, cancer, and ageing

被引：325

作者：

Hsieh, Peggy ^{[1
]}

Yamane, Kazuhiko ^{[1
]}

机构：

[1] NIDDKD, Genet & Biochem Branch, Natl Inst Hlth, Bethesda, MD 20892 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2008年 / 129卷 / 7-8期

关键词：

mismatch repair; HNPCC; ageing; genome instability; MutS; MutL;

D O I：

10.1016/j.mad.2008.02.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important cellular functions. In its role in post-replication repair, MMR safeguards the genome correcting base mispairs arising as a result of replication errors. Loss of MMR results in greatly increased rates of spontaneous mutation in organisms ranging from bacteria to humans. Mutations in MMR genes cause hereditary nonpolyposis colorectal cancer, and loss of MMR is associated with a significant fraction of sporadic cancers. Given its prominence in mutation avoidance and its ability to target a range of DNA lesions, MMR has been under investigation in studies of ageing mechanisms. This review summarizes what is known about the molecular details of the MMR pathway and the role of MMR proteins in cancer susceptibility and ageing. Published by Elsevier Ireland Ltd.

引用

页码：391 / 407

页数：17

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