The cell biology of Alzheimer's disease: uncovering the secrets of secretases

被引：147

作者：

Walter, J ^{[1
]}

Kaether, C ^{[1
]}

Steiner, H ^{[1
]}

Haass, C ^{[1
]}

机构：

[1] Univ Munich, Dept Biochem, Adolf Butenandt Inst, Lab Alzheimers & Parkinsons Dis Res, D-80336 Munich, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(00)00253-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Progress has been made in characterizing the secretases involved in endoproteolytic processing of the beta -amyloid precursor protein - the precursor of the amyloid beta -peptide (A beta), which is the main constituent of amyloid plaques that form in the brains of patients with Alzheimer's disease. It is now thought that A beta is pivotal in the pathogenesis of Alzheimer's disease, and that reducing brain A beta levels may help to treat or prevent the disease. Two essential factors for the proteolytic generation of A beta have been identified, beta -secretase and the presenilins, which might aid the design of drugs against this disease.

引用

页码：585 / 590

页数：6

共 67 条

[1] Presenilin 1 controls γ-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons [J].

Annaert, WG ;

Levesque, L ;

Craessaerts, K ;

Dierinck, I ;

Snellings, G ;

Westaway, D ;

George-Hyslop, PS ;

Cordell, B ;

Fraser, P ;

De Strooper, B .

JOURNAL OF CELL BIOLOGY, 1999, 147 (02) :277-294

[2]

Baumeister R, 1997, Genes Funct, V1, P149

[3] Post-translational processing of β-secretase (β-amyloid-converting enzyme) and its ectodomain shedding -: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production [J].

Benjannet, S ;

Elagoz, A ;

Wickham, L ;

Mamarbachi, M ;

Munzer, JS ;

Basak, A ;

Lazure, C ;

Cromlish, JA ;

Sisodia, S ;

Checler, F ;

Chrétien, M ;

Seidah, NG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (14) :10879-10887

[4] Expression analysis of BACE2 in brain and peripheral tissues [J].

Bennett, BD ;

Babu-Khan, S ;

Loeloff, R ;

Louis, JC ;

Curran, E ;

Citron, M ;

Vassar, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) :20647-20651

[5]

Bennett BD, 2001, J BIOL CHEM, V276, P15561

[6] Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor [J].

Buxbaum, JD ;

Liu, KN ;

Luo, YX ;

Slack, JL ;

Stocking, KL ;

Peschon, JJ ;

Johnson, RS ;

Castner, BJ ;

Cerretti, DP ;

Black, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :27765-27767

[7] BACE1 is the major β-secretase for generation of Aβ peptides by neurons [J].

Cai, HB ;

Wang, YS ;

McCarthy, D ;

Wen, HJ ;

Borchelt, DR ;

Price, DL ;

Wong, PC .

NATURE NEUROSCIENCE, 2001, 4 (03) :233-234

[8] A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60 [J].

Cao, XW ;

Südhof, TC .

SCIENCE, 2001, 293 (5527) :115-120

[9] Maturation and pro-peptide cleavage of β-secretase [J].

Capell, A ;

Steiner, H ;

Willem, M ;

Kaiser, H ;

Meyer, C ;

Walter, J ;

Lammich, S ;

Multhaup, G ;

Haass, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (40) :30849-30854

[10] The multiple paradoxes of presenilins [J].

Checler, F .

JOURNAL OF NEUROCHEMISTRY, 2001, 76 (06) :1621-1627

← 1 2 3 4 5 6 7 →