Ring-closing metathesis strategy to unsaturated γ- and δ-lactones:: Synthesis of hydroxyethylene isostere for protease inhibitors

被引：149

作者：

Ghosh, AK ^{[1
]}

Cappiello, J ^{[1
]}

Shin, D ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(98)00887-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ring-closing olefin metathesis of acrylates derived from allylic and home allylic alcohols in the presence of the Grubbs' catalyst (10-15 mol%) and titanium isopropoxide (0.3-3 equiv) provided ready access to alpha, beta-unsaturated gamma- and delta-lactones and an important dipeptide isostere intermediate. (C) 1998 Elsevier Science Ltd. An rights reserved.

引用

页码：4651 / 4654

页数：4

共 25 条

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