Comparative in vitro activities of daptomycin and vancomycin against resistant gram-positive pathogens

被引：84

作者：

Snydman, DR

Jacobus, NV

McDermott, LA

Lonks, JR

Boyce, JM

机构：

[1] New England Med Ctr, Boston, MA 02111 USA

[2] Miriam Hosp, Acad Med Ctr, Providence, RI 02906 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 12期

关键词：

D O I：

10.1128/AAC.44.12.3447-3450.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activity of daptomycin against 224 current gram-positive clinical isolates including vancomycin-resistant Enterococcus faecium (VREF), methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus spp. (MRSS), and penicillin-resistant Steptococcus pneumoniae (PRSP) was evaluated. The MICs at which 90% of isolates are inhibited for daptomycin and vancomycin, respectively, were as follows: MRSA, 1 and 2 mug/ml; MRSS, 1 and 4 mug/ml; PRSP, 1 and 0.5 mug/ml; and VREF, 2 and >64 mug/ml. Daptomycin was bactericidal against 82% of 17 VREF isolates. The antibacterial activity of daptomycin was strongly dependent on the calcium concentration of the medium. Daptomycin was active against all gram-positive cocci tested.

引用

收藏

页码：3447 / 3450

页数：4

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