TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy

被引：16

作者：

Canhao, Helena ^{[1
,2
,3
]}

Rodrigues, AnaMaria ^{[1
,2
]}

Santos, Maria Jose ^{[1
,4
]}

Carmona-Fernandes, Diana ^{[1
]}

Bettencourt, Bruno F. ^{[5
,6
]}

Cui, Jing ^{[3
]}

Rocha, Fabiana L. ^{[5
,6
]}

Silva, Jose Canas ^{[4
]}

Polido-Pereira, Joaquim ^{[1
,2
]}

Silva, Jose Alberto Pereira ^{[2
]}

Costa, Jose Antonio ^{[7
]}

Araujo, Domingos ^{[7
]}

Silva, Candida ^{[8
]}

Santos, Helena ^{[8
]}

Duarte, Catia ^{[9
]}

Caliz, Rafael ^{[10
]}

Filipescu, Ileana ^{[11
]}

Pimentel-Santos, Fernando ^{[12
,13
]}

Branco, Jaime ^{[12
,13
]}

Sainz, Juan ^{[14
]}

Plenge, Robert M. ^{[3
,15
]}

Solomon, Daniel H. ^{[3
,16
]}

Bruges-Armas, Jacome ^{[5
,6
]}

Da Silva, Jose Antonio P. ^{[9
]}

Fonseca, Joao Eurico ^{[1
,2
]}

Karlson, Elizabeth W. ^{[3
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Mol Med, Rheumatol Res Unit, P-1649028 Lisbon, Portugal

[2] Hosp Santa Maria CHLN, Lisbon Acad Med Ctr, Dept Rheumatol, P-1649035 Lisbon, Portugal

[3] Brigham andWomens Hosp, Div Rheumatol Allergy & Immunol, Clin Sci Sect, Boston, MA 02115 USA

[4] Hosp Garcia de Orta, Dept Rheumatol, P-2805267 Almada, Portugal

[5] Hosp Santo Espirito da Ilha Terceira, SEEBMO, P-9700049 Angra Do Heroismo, Portugal

[6] Inst Mol & Cell Biol IBMC, P-4150180 Oporto, Portugal

[7] Conde Bertiandos Hosp ULSAM, Dept Rheumatol, P-4990041 Ponte do Lima, Portugal

[8] Inst Portugues Reumatol, Lisbon, Portugal

[9] Ctr Hosp Univ Coimbra, Dept Rheumatol, P-3000076 Coimbra, Portugal

[10] Virgen de las Nieves Univ Hosp, Dept Rheumatol, Granada, Spain

[11] Univ Med & Pharm Iuliu Hatieganu, Dept Rheumatol, Cluj Napoca, Romania

[12] Univ Nova Lisboa, Fac Ciencias Med, CEDOC, P-1200 Lisbon, Portugal

[13] Hosp Egas Moniz CHLO, Dept Rheumatol, P-1349019 Lisbon, Portugal

[14] Univ Granada, PTS Granada, Andalusian Reg Govt, GENYO Ctr Genom & Oncol Res,Pfizer,Genom Oncol Ar, Granada, Spain

[15] Broad Inst Harvard, Cambridge, MA USA

[16] Brigham & Womens Hosp, Div Pharmacoepidemiol, Boston, MA USA

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

GENOME-WIDE ASSOCIATION; INCREASED MORTALITY; SUSCEPTIBILITY; HLA-DRB1; POLYMORPHISM; PTPN22; CLASSIFICATION; METHOTREXATE; REMISSION; ANTIBODY;

D O I：

10.1155/2015/490295

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Background. The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. Methods. We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to confirm our findings, we pooled our population with 265 Spanish patients. Results. No association was found between PTPRC rs10919563 allele and anti-TNF treatment response, neither in Portuguese modeling for several clinical variables nor in the overall population combining Portuguese and Spanish patients. The minor allele for RA susceptibility, rs3761847 SNP in TR Lambda F1/C5 region, was associated with a poor response in linear and logistic univariate and multivariate regression analyses. No association was observed with the other allellic variants. Results were confirmed in the pooled analysis. Conclusion. This study did not replicate the association between PTPRC and the response to anti-TNF treatment in our Southern European population. We found that TR Lambda F1/C5 risk RA variants potentially influence anti-TNF treatment response.

引用

页数：9

共 39 条

[1]

THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[2]

New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility:: a combined analysis of worldwide samples [J].

Barnetche, Thomas ;

Constantin, Arnaud ;

Cantagrel, Alain ;

Cambon-Thomsen, Anne ;

Gourraud, Pierre-Antoine .

ARTHRITIS RESEARCH & THERAPY, 2008, 10 (01)

[3]

Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility [J].

Barton, Anne ;

Thomson, Wendy ;

Ke, Xiayi ;

Eyre, Steve ;

Hinks, Anne ;

Bowes, John ;

Gibbons, Laura ;

Plant, Darren ;

Wilson, Anthony G. ;

Marinou, Ioanna ;

Morgan, Ann ;

Emery, Paul ;

Steer, Sophia ;

Hocking, Lynne ;

Reid, David M. ;

Wordsworth, Paul ;

Harrison, Pille ;

Worthington, Jane .

HUMAN MOLECULAR GENETICS, 2008, 17 (15) :2274-2279

[4]

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[5]

Comparative effectiveness and predictors of response to tumour necrosis factor inhibitor therapies in rheumatoid arthritis [J].

Canhao, Helena ;

Rodrigues, Ana Maria ;

Mourao, Ana Filipa ;

Martins, Fernando ;

Santos, Maria Jose ;

Canas-Silva, Jose ;

Polido-Pereira, Joaquim ;

Pereira Silva, Jose Alberto ;

Costa, Jose Antonio ;

Araujo, Domingos ;

Silva, Candida ;

Santos, Helena ;

Duarte, Catia ;

Pereira da Silva, Jose Antonio ;

Pimentel-Santos, Fernando M. ;

Branco, Jaime Cunha ;

Karlson, Elizabeth W. ;

Fonseca, Joao Eurico ;

Solomon, Daniel H. .

RHEUMATOLOGY, 2012, 51 (11) :2020-2026

[6]

Canhao H, 2011, ACTA REUMATOL PORT, V36, P45

[7]

The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept [J].

Criswell, LA ;

Lum, RF ;

Turner, KN ;

Woehl, B ;

Zhu, YQ ;

Wang, JY ;

Tiwari, HK ;

Edberg, JC ;

Kimberly, RP ;

Moreland, LW ;

Seldin, MF ;

Bridges, SL .

ARTHRITIS AND RHEUMATISM, 2004, 50 (09) :2750-2756

[8]

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis [J].

Cui, Jing ;

Stahl, Eli A. ;

Saevarsdottir, Saedis ;

Miceli, Corinne ;

Diogo, Dorothee ;

Trynka, Gosia ;

Raj, Towfique ;

Mirkov, Masa Umicevic ;

Canhao, Helena ;

Ikari, Katsunori ;

Terao, Chikashi ;

Okada, Yukinori ;

Wedren, Sara ;

Askling, Johan ;

Yamanaka, Hisashi ;

Momohara, Shigeki ;

Taniguchi, Atsuo ;

Ohmura, Koichiro ;

Matsuda, Fumihiko ;

Mimori, Tsuneyo ;

Gupta, Namrata ;

Kuchroo, Manik ;

Morgan, Ann W. ;

Isaacs, John D. ;

Wilson, Anthony G. ;

Hyrich, Kimme L. ;

Herenius, Marieke ;

Doorenspleet, Marieke E. ;

Tak, Paul-Peter ;

Crusius, J. Bart A. ;

van der Horst-Bruinsma, Irene E. ;

Wolbink, Gert Jan ;

van Riel, Piet L. C. M. ;

van de Laar, Mart ;

Guchelaar, Henk-Jan ;

Shadick, Nancy A. ;

Allaart, Cornelia F. ;

Huizinga, Tom W. J. ;

Toes, Rene E. M. ;

Kimberly, Robert P. ;

Bridges, S. Louis, Jr. ;

Criswell, Lindsey A. ;

Moreland, Larry W. ;

Fonseca, Joao Eurico ;

de Vries, Niek ;

Stranger, Barbara E. ;

De Jager, Philip L. ;

Raychaudhuri, Soumya ;

Weinblatt, Michael E. ;

Gregersen, Peter K. .

PLOS GENETICS, 2013, 9 (03)

[9]

Rheumatoid Arthritis Risk Allele PTPRC Is Also Associated With Response to Anti-Tumor Necrosis Factor α Therapy [J].

Cui, Jing ;

Saevarsdottir, Saedis ;

Thomson, Brian ;

Padyukov, Leonid ;

van der Helm-van Mil, Annette H. M. ;

Nititham, Joanne ;

Hughes, Laura B. ;

de Vries, Niek ;

Raychaudhuri, Soumya ;

Alfredsson, Lars ;

Askling, Johan ;

Wedren, Sara ;

Ding, Bo ;

Guiducci, Candace ;

Wolbink, Gert Jan ;

Crusius, J. Bart A. ;

van der Horst-Bruinsma, Irene E. ;

Herenius, Marieke ;

Weinblatt, Michael E. ;

Shadick, Nancy A. ;

Worthington, Jane ;

Batliwalla, Franak ;

Kern, Marlena ;

Morgan, Ann W. ;

Wilson, Anthony G. ;

Isaacs, John D. ;

Hyrich, Kimme ;

Seldin, Michael F. ;

Moreland, Larry W. ;

Behrens, Timothy W. ;

Allaart, Cornelia F. ;

Criswell, Lindsey A. ;

Huizinga, Tom W. J. ;

Tak, Paul P. ;

Bridges, S. Louis, Jr. ;

Toes, Rene E. M. ;

Barton, Anne ;

Klareskog, Lars ;

Gregersen, Peter K. ;

Karlson, Elizabeth W. ;

Plenge, Robert M. .

ARTHRITIS AND RHEUMATISM, 2010, 62 (07) :1849-1861

[10]

Fabris M, 2002, Reumatismo, V54, P19

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