Osteoporosis in patients with diabetes mellitus

被引:377
作者
Hofbauer, Lorenz C.
Brueck, Carolin C.
Singh, Shiv K.
Dobnig, Harald
机构
[1] Tech Univ Dresden, Med Ctr, Dept Med 3, Div Endocrinol Diabet & Metab Bone Dis, D-01307 Dresden, Germany
[2] Univ Marburg, Dept Med, Div Gastroenterol & Endocrinol, Marburg, Germany
[3] Med Univ Graz, Dept Med, Div Endocrinol & Nucl Med, Graz, Austria
关键词
diabetes mellitus; insulin; osteoblasts; osteoclast; osteoporosis;
D O I
10.1359/JBMR.070510
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Demographic trends with longer life expectancy and a lifestyle characterized by low physical activity and high-energy food intake contribute to an increasing incidence of diabetes mellitus and osteoporosis. Diabetes mellitus is a risk factor for osteoporotic fractures. Patients with recent onset of type 1 diabetes mellitus may have impaired bone formation because of the absence of the anabolic effects of insulin and amylin, whereas in long-standing type I diabetes mellitus, vascular complications may account for low bone mass and increased fracture risk. Patients with type 2 diabetes mellitus display an increased fracture risk despite a higher BMD, which is mainly attributable to the increased risk of falling. Strategies to improve BMD and to prevent osteoporotic fractures in patients with type I diabetes mellitus may include optimal glycemic control and aggressive prevention and treatment of vascular complications. Patients with type 2 diabetes mellitus may additionally benefit from early visual assessment, regular exercise to improve muscle strength and balance, and specific measures for preventing falls.
引用
收藏
页码:1317 / 1328
页数:12
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