Regulation of Ocellar Specification and Size by Twin of Eyeless and Homothorax

被引：26

作者：

Brockmann, Anette ^{[1
]}

Dominguez-Cejudo, Maria A. ^{[1
]}

Amore, Gabriele ^{[2
]}

Casares, Fernando ^{[1
]}

机构：

[1] Campus Univ Pablo Olavide, CABD, CSIC UPO, Seville 41013, Spain

[2] Stn Zool Anton Dohrn SZN, Seville, Spain

来源：

DEVELOPMENTAL DYNAMICS | 2011年 / 240卷 / 01期

关键词：

toy; hth; retinal determination gene network; visual organ development; Drosophila; eya; so; DROSOPHILA HEAD DEVELOPMENT; DETERMINATION GENE NETWORK; EYES-ABSENT GENE; SINE-OCULIS; VISUAL-SYSTEM; HOMEOBOX GENE; ORTHODENTICLE; EXPRESSION; HEDGEHOG; WINGLESS;

D O I：

10.1002/dvdy.22494

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100123 [人体微生态学]; 100210 [外科学];

摘要：

The retinal determination gene network (RDGN) constitutes a paradigm of a gene network controlling organ specification and growth. In this study, we probed the RDGN in the Drosophila ocelli, a set of simple eyes located on the fly's dorsal head, by studying the expression, regulation, and function of toy, hth, eya, and so, members of the Pax6, Meis, Eya, and Six gene families. Our results highlight the role of the pax6 gene toy, together with the hh signaling pathway, in the initiation of eya and so expression; the engagement of eya and so in a feedback loop necessary for their full expression; and the interplay between hh signaling and hth as a mechanism of organ size control, as general regulatory steps in the specification of visual organs. Developmental Dynamics 240: 75-85, 2011. (C) 2010 Wiley-Liss, Inc.

引用

页码：75 / 85

页数：11

共 52 条

[1]

Amin A, 1999, DEVELOPMENT, V126, P2623

[2]

Size matters: The contribution of cell proliferation to the progression of the specification Drosophila eye gene regulatory network [J].

Amore, Gabriele ;

Casares, Fernando .

DEVELOPMENTAL BIOLOGY, 2010, 344 (02) :569-577

[3]

Control of Drosophila eye specification by Wingless signalling [J].

Baonza, A ;

Freeman, M .

DEVELOPMENT, 2002, 129 (23) :5313-5322

[4]

Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila [J].

Bessa, J ;

Casares, F .

DEVELOPMENT, 2005, 132 (22) :5011-5020

[5]

Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt [J].

Bessa, J ;

Gebelein, B ;

Pichaud, F ;

Casares, F ;

Mann, RS .

GENES & DEVELOPMENT, 2002, 16 (18) :2415-2427

[6]

Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila [J].

Blanco, Jorge ;

Pauli, Tobias ;

Seimiya, Makiko ;

Udolph, Gerald ;

Gehring, Walter J. .

DEVELOPMENTAL BIOLOGY, 2010, 344 (02) :1088-1099

[7]

Wingless and Hedgehog signaling pathways regulate orthodenticle and eyes absent during ocelli development in Drosophila [J].

Blanco, Jorge ;

Seimiya, Makiko ;

Pauli, Tobias ;

Reichert, Heinrich ;

Gehring, Walter J. .

DEVELOPMENTAL BIOLOGY, 2009, 329 (01) :104-115

[8]

THE EYES ABSENT GENE - GENETIC-CONTROL OF CELL-SURVIVAL AND DIFFERENTIATION IN THE DEVELOPING DROSOPHILA EYE [J].

BONINI, NM ;

LEISERSON, WM ;

BENZER, S .

CELL, 1993, 72 (03) :379-395

[9]

Bonini NM, 1997, DEVELOPMENT, V124, P4819

[10]

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube [J].

Briscoe, J ;

Chen, Y ;

Jessell, TM ;

Struhl, G .

MOLECULAR CELL, 2001, 7 (06) :1279-1291

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