The effect of oral prednisolone with chronic obstructive pulmonary disease undergoing coronary artery bypass surgery

被引:27
作者
Bingol, H [1 ]
Cingoz, F
Balkan, A
Kilic, S
Bolcal, C
Demirkilic, U
Tatar, H
机构
[1] Gulhane Mil Med Acad, Dept Cardiovasc Surg, TR-06018 Ankara, Turkey
[2] Gulhane Mil Med Acad, Dept Pulm Med, TR-06018 Ankara, Turkey
[3] Gulhane Mil Med Acad, Dept Epidemiol, TR-06018 Ankara, Turkey
关键词
D O I
10.1111/j.1540-8191.2005.200392.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Chronic obstructive pulmonary disease is still one of the most important problems in patients undergoing cardiopulmonary bypass. The purpose of this prospective study was to assess the beneficial effects of oral prednisolone on pulmonary functions in patients undergoing cardiopulmonary bypass. Methods: Forty patients with chronic obstructive pulmonary disease were divided into two groups randomly and were given 20 mg oral prednisolone once daily perioperatively (Group I, n = 20) or identical placebo (Group II, n = 20). FEV1 values, dates of intensive care unit and hospital stays of the two groups were compared. Results: FEV, values during the admission to our hospital were similar in each group mean predicted FEV1: 56.7 +/- 5.35% in Group I and 57.2 +/- 4.88% in Group II (p = 0.759). After 10 days of oral prednisolone treatment in Group I, predicted FEV, values were significantly different between two groups (63.2% +/- 4.24 and 57.9% +/- 4.38) (p = 0.0001). While predicted FEV1 values revealed difference between two groups at the date of discharge (p = 0.0001) the values became similar at the third month (55.6% +/- 4.09 in Group I and 55.45% +/- 3.87 in Group II) (p = 0.897). Conclusion: Various types of complications may occur after cardiopulmonary bypass. Oral prednisolone not only decreases the rates of complications (reintubation, intubation times, and rhythm disturbances) but also decreases the cost of cardiac operations according to shorter hospital stays.
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页码:252 / 256
页数:5
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