Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1)

被引:132
作者
Kusuhara, H [1 ]
Sugiyama, Y [1 ]
机构
[1] Univ Tokyo, Fac Pharmaceut Sci, Dept Biopharmaceut, Tokyo 113, Japan
关键词
D O I
10.1016/S1359-6446(00)01632-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Penetration through the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSF B) is necessary if a drug is to achieve the required concentration for a desired pharmacological effect. Efflux transport systems at the BBB and BCSFB provide a protective barrier function by removing drugs from the brain or cerebrospinal fluid and transferring them to the systemic circulation, respectively; several transporters at the BBB and BCSFB have been identified. Efflux transport should be taken into consideration during drug development to improve brain penetration and to avoid drug-drug interactions involving these transporters and subsequent side effects.
引用
收藏
页码:150 / 156
页数:7
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