Tyrosinase and related proteins in mammalian pigmentation

被引：347

作者：

delMarmol, V

Beermann, F

机构：

[1] SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND

[2] FREE UNIV BRUSSELS,INST JULES BORDET,LOCE,B-1000 BRUSSELS,BELGIUM

来源：

FEBS LETTERS | 1996年 / 381卷 / 03期

关键词：

human; mouse; pigmentation; TRP-1; TRP-2; tyrosinase;

D O I：

10.1016/0014-5793(96)00109-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tyrosinase is the hey enzyme in pigment synthesis, initiating a cascade of reactions which convert the amino acid tyrosine to the melanin biopolymer. Two other tyrosinase-related proteins (TRP) are known, TRP-1 (probably DHICAoxidase) and TRP-2 (DOPAchrome tautomerase). These proteins show about 40% homology, and recent results have indicated that the genes might be derived from a common ancestor, We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man.

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页码：165 / 168

页数：4

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