Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis

被引:249
作者
Ota, H [1 ]
Igarashi, S
Sasaki, M
Tanaka, T
机构
[1] Akita Univ, Sch Med, Dept Obstet & Gynecol, Akita 0108543, Japan
[2] Koto Gen Hosp, Hachirogata Town, Akita 0181605, Japan
关键词
adenomyosis; cyclooxygenase; endometriosis; endometrium; prostaglandin;
D O I
10.1093/humrep/16.3.561
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The objective of this study was to determine the distribution of cyclooxygenase-2 (COX-2) in eutopic and ectopic endometria in endometriosis and adenomyosis. The subjects were 35 patients with endometriosis diagnosed by laparoscopy, 33 patients with histologically confirmed adenomyosis and 50 female controls with normal fecundity. Expression of COX-2 was immunohistochemically investigated in tissues from eutopic endometrium and myometrium and ectopic endometrium of the wall of ovarian chocolate cysts using polyclonal antibody. Surface epithelial cells, endometrial glandular epithelial cells or stromal cells were assessed, Cells were semi-quantitatively assessed on a scale of 1 to 5 using a nomogram created from positive cell count and the degree of staining, COX-2 expression in surface and glandular epithelia of the control group varied markedly during the menstrual cycle. It was lowest in the early proliferative phase and gradually increased thereafter. It remained high throughout the secretory phase. However, in patients with endometriosis, expression of COX-2 in glandular epithelium was higher than that in the control group, though it varied throughout the menstrual cycle. On the other hand, there was no variation in expression of COX-2 in the adenomyosis group during the menstrual cycle, and it was lower than that in the endometriosis group in all phases, Pronounced COX-2 expression was observed in glandular cells from ectopic endometrial tissue of ovarian chocolate cyst walls in all cases regardless of the menstrual phase. In summary, increased COX-2 expression in eutopic and ectopic endometria was believed to be strongly correlated with pathological abnormalities in these disorders.
引用
收藏
页码:561 / 566
页数:6
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