Quorum Sensing in Aeromonas Species Isolated from Patients in Malaysia

被引：47

作者：

Chan, Kok-Gan ^{[1
]}

Puthucheary, Savithri D. ^{[2
]}

Chan, Xin-Yue ^{[1
]}

Yin, Wai-Fong ^{[1
]}

Wong, Cheng-Siang ^{[1
]}

Too, Wah-Seng See ^{[1
]}

Chua, Kek-Heng ^{[3
]}

机构：

[1] Univ Malaya, Inst Biol Sci, Div Genet & Mol Biol, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Dept Mol Med, Fac Med, Kuala Lumpur 50603, Malaysia

来源：

CURRENT MICROBIOLOGY | 2011年 / 62卷 / 01期

关键词：

VIRULENCE; HYDROPHILA; SALMONICIDA;

D O I：

10.1007/s00284-010-9689-z

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial quorum sensing signal molecules called N-acylhomoserine lactone (AHL) controls the expression of virulence determinants in many Gram-negative bacteria. We determined AHL production in 22 Aeromonas strains isolated from various infected sites from patients (bile, blood, peritoneal fluid, pus, stool and urine). All isolates produced the two principal AHLs, N-butanoylhomoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). Ten isolates also produced additional AHLs. This report is the first documentation of Aeromonas sobria producing C6-HSL and two additional AHLs with N-acyl side chain longer than C-6. Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen.

引用

页码：167 / 172

页数：6

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