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The glial identity of neural stem cells

被引：554
作者：
Doetsch, F [1 ]
机构：
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
来源：
NATURE NEUROSCIENCE | 2003年 / 6卷 / 11期
关键词：
D O I：
10.1038/nn1144
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glia are the most numerous cells in the brain, and their many diverse functions highlight their essential role in the nervous system. Recent studies have revealed an unexpected new role for glia in a wide variety of species, that of stem cells/progenitors in the adult and embryonic brain. Differentiation along the glial lineage may be a default state of development reflected in the progression of stem cells along the neuroepithelial radial glia astrocyte lineage.
引用
收藏
页码：1127 / 1134
页数：8
相关论文
共 100 条
  • [1] Alvarez-Buylla A, 1998, J NEUROSCI, V18, P1020
  • [2] A unified hypothesis on the lineage of neural stem cells
    Alvarez-Buylla, A
    García-Verdugo, JM
    Tramontin, AD
    [J]. NATURE REVIEWS NEUROSCIENCE, 2001, 2 (04) : 287 - 293
  • [3] MIGRATION OF YOUNG NEURONS IN ADULT AVIAN BRAIN
    ALVAREZBUYLLA, A
    NOTTEBOHM, F
    [J]. NATURE, 1988, 335 (6188) : 353 - 354
  • [4] Initial stages of radial glia astrocytic transformation in the early postnatal anterior subventricular zone
    Alves, JAJ
    Barone, P
    Engelender, S
    Fróes, MM
    Menezes, JRL
    [J]. JOURNAL OF NEUROBIOLOGY, 2002, 52 (03): : 251 - 265
  • [5] Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Belachew, S
    Chittajallu, R
    Aguirre, AA
    Yuan, XQ
    Kirby, M
    Anderson, S
    Gallo, V
    [J]. JOURNAL OF CELL BIOLOGY, 2003, 161 (01) : 169 - 186
  • [6] ASTROCYTE-SPECIFIC PROTEIN AND RADIAL GLIA IN CEREBRAL-CORTEX OF NEWBORN RAT
    BIGNAMI, A
    DAHL, D
    [J]. NATURE, 1974, 252 (5478) : 55 - 56
  • [7] CAJAL RY, 1995, HISTOLOGY NERVOUS SY, V1
  • [8] LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal
    Capela, A
    Temple, S
    [J]. NEURON, 2002, 35 (05) : 865 - 875
  • [9] Becoming a new neuron in the adult olfactory bulb
    Carleton, A
    Petreanu, LT
    Lansford, R
    Alvarez-Buylla, A
    Lledo, PM
    [J]. NATURE NEUROSCIENCE, 2003, 6 (05) : 507 - 518
  • [10] Chiasson BJ, 1999, J NEUROSCI, V19, P4462
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