Use of antidepressant medications during pregnancy: a multisite study

被引：312

作者：

Andrade, Susan E. ^{[1
,2
,3
]}

Raebel, Marsha A. ^{[3
,4
]}

Brown, Jeffrey ^{[3
,5
,6
]}

Lane, Kimberly ^{[3
,5
,6
]}

Livingston, James ^{[3
,5
,6
]}

Boudreau, Denise ^{[3
,7
]}

Rolnick, Sharon J. ^{[3
,8
]}

Roblin, Douglas ^{[3
,9
]}

Smith, David H. ^{[3
,10
]}

Willy, Mary E. ^{[11
]}

Staffa, Judy A. ^{[11
]}

Platt, Richard ^{[3
]}

机构：

[1] Univ Massachusetts, Sch Med, Fallon Fdn, Meyers Primary Care Inst, Worcester, MA 01605 USA

[2] Fallon Commun Hlth Plan, Worcester, MA USA

[3] Ctr Educ & Res Therapeut, HMO Res Network, Denver, CO USA

[4] Kaiser Permanente Colorado, Denver, CO USA

[5] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA 02115 USA

[6] Harvard Pilgrim Hlth Care, Boston, MA USA

[7] Grp Hlth Cooperat Puget Sound, Ctr Hlth Studies, Seattle, WA 98101 USA

[8] Hlth Partners Res Fdn, Minneapolis, MN USA

[9] Kaiser Permanente Georgia, Atlanta, GA USA

[10] Kaiser Permanente NW, Portland, OR USA

[11] US FDA, Ctr Drug Evaluat & Res, Off Surveillance & Epidemiol, Silver Spring, MD USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2008年 / 198卷 / 02期

关键词：

antidepressant drugs; pregnancy;

D O I：

10.1016/j.ajog.2007.07.036

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States. STUDY DESIGN: A retrospective study was conducted using the automated databases of 7 health plans. Women who delivered an infant in a hospital were identified. Antidepressant drug use was evaluated assuming a gestational duration of 270 days. RESULTS: Among the 118,935 deliveries occurring from 2001-2005, 6.6% of women were dispensed an antidepressant during pregnancy. Antidepressant drug use increased from 2.0% in 1996 to 7.6% of deliveries in 2004 and 2005. Selective serotonin re-uptake inhibitor use increased from 1.5% in 1996 to 6.4% in 2004 and 6.2% in 2005. CONCLUSION: Our finding that nearly 8% of pregnant women were prescribed antidepressants drugs during the years 2004 and 2005 highlights the importance of understanding the effects of these medications on the developing fetus and on the pregnant woman.

引用

页码：194.e1 / 194.e5

页数：5

共 21 条

[1] Alwan S, 2005, Birth Defects Research, V73, P291
[2] Prescription drug use in pregnancy
Andrade, Susan E.
Gurwitz, Jerry H.
Davis, Robert L.
Chan, K. Arnold
Finkelstein, Jonathan A.
Fortman, Kris
McPhillips, Heather
Raebel, Marsha A.
Roblin, Douglas
Smith, David H.
Yood, Marianne Ulcickas
Morse, Abraham N.
Platt, Richard
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2004, 191 (02) : 398 - 407
[3] Prevalence of depression during pregnancy: Systematic review
Bennett, HA
Einarson, A
Taddio, A
Koren, G
Einarson, TR
[J]. OBSTETRICS AND GYNECOLOGY, 2004, 103 (04) : 698 - 709
[4] First trimester exposure to paroxetine and risk of cardiac malformations in infants:: The importance of dosage
Berard, Anick
Ramos, Elodie
Rey, Evelyne
Blais, Lucie
St. Andre, Martin
Oraichi, Driss
[J]. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, 2007, 80 (01) : 18 - 27
[5] Bonari L, 2004, CAN FAM PHYSICIAN, V50, P37
[6] Perinatal Risks of Untreated Depression During Pregnancy
Bonari, Lori
Pinto, Natasha
Ahn, Eric
Einarson, Adrienne
Steiner, Meir
Koren, Gideon
[J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2004, 49 (11): : 726 - 735
[7] *CDCP, HLTH MAINT ORG HMOS
[8] Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
Chambers, CD
Hernandez-Diaz, S
Van Marter, LJ
Werler, MM
Louik, C
Jones, KL
Mitchell, AA
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) : 579 - 587
[9] Birth outcomes in pregnant women taking fluoxetine
Chambers, CD
Johnson, KA
Dick, LM
Felix, RJ
Jones, KL
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (14) : 1010 - 1015
[10] Chan KA, 2005, PHARMACOEPIDEMIOLOGY, 4TH EDITION, P261

← 1 2 3 →