Amplification at 9p in cervical carcinoma by comparative genomic hybridization

被引：7

作者：

Jee, KJ

Kim, YT

Kim, KR

Aalto, Y

Knuutila, S

机构：

[1] Univ Helsinki, Haartman Inst, Dept Med Genet, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Cent Hosp, FIN-00014 Helsinki, Finland

[3] Univ Ulsan, Coll Med, ASAN Med Ctr, Dept Obstet & Gynaecol, Seoul, South Korea

[4] Univ Ulsan, Coll Med, ASAN Med Ctr, Dept Pathol, Seoul, South Korea

来源：

ANALYTICAL CELLULAR PATHOLOGY | 2001年 / 22卷 / 03期

关键词：

cervical cancer; CGH; amplification at 9p21-pter;

D O I：

10.1155/2001/174645

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA copy number changes were studied by comparative genomic hybridization on 10 tumor specimens of squamous cell carcinoma of cervix obtained from Korean patients, DNA was extracted from paraffin-embedded sections after removal of non-malignant cells by microdissection technique. Copy number changes were found in 8/10 tumors. The most frequent changes were chromosome 19 gains (n = 6) and losses on chromosomes 4 (n = 4), 5 (n = 3), and 3p (n = 3), A novel finding was amplification in chromosome arm 9p21-pter in 2 cases. Gains in 1, 3q, 5p, 6p, 8q, 16p, 17, and 20q and losses at 2q, 6q, 8p, 9q, 10p, 11, 13, 16q, and 18q were observed in at least one of the cases.

引用

页码：159 / 163

页数：5

共 21 条

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