Evolution of cyclophilin A and TRIMCyp retrotransposition in new world primates

被引:38
作者
Ribeiro, IP
Menezes, AN
Moreira, MAM
Bonvicino, CR
Seuánez, HN
Soares, MA
机构
[1] Univ Fed Rio de Janeiro, Dept Genet, BR-21949570 Rio De Janeiro, Brazil
[2] Inst Nacl Canc, Div Genet, BR-20231 Rio De Janeiro, Brazil
关键词
D O I
10.1128/JVI.79.23.14998-15003.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Host cell factors modulate retroviral infections. Among those, cyclophilin A (CypA) promotes virus infectivity by facilitating virus uncoating or capsid unfolding or by preventing retroviral capsid interaction with cellular restriction factors. In Aotus species, a retrotransposed copy of CypA inserted into the tripartite motif 5 (TRIM5) gene encodes a fusion protein which may block human immunodeficiency virus type I by targeting the incoming virus to ubiquitin-ligated degradation or by interfering with normal uncoating of the incoming particle, rendering those monkeys resistant to infection. In this study, we have extensively analyzed representative specimens from all New World primate genera and shown that the retrotransposed CypA copy is only present in Aotus. We have shown that this inserted copy diverged from its original counterpart and that this occurred prior to Aotus radiation, although no positive selection was observed. Finally, our data underscores the need for a precise taxonomic identification of primate species used as models for retroviral infections and novel antiviral approaches.
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收藏
页码:14998 / 15003
页数:6
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