Comparison of hyperbaric oxygen and medical ozone therapies in a rat model of experimental distal colitis

被引：27

作者：

Altinel, Ozcan ^{[1
]}

Demirbas, Seref ^{[2
]}

Cakir, Erdinc ^{[3
]}

Yaman, Halil ^{[3
]}

Ozerhan, Ismail H. ^{[1
]}

Duran, Eyup ^{[1
]}

Cayci, Tuncer ^{[3
]}

Akgul, Emin O. ^{[3
]}

Ersoz, Nail ^{[1
]}

Uysal, Bulent ^{[4
]}

Kurt, Bulent ^{[5
]}

Yasar, Mehmet ^{[1
]}

Oter, Sukru ^{[4
]}

Peker, Yusuf ^{[1
]}

机构：

[1] Gulhane Mil Med Acad, Dept Gen Surg, Ankara, Turkey

[2] Gulhane Mil Med Acad, Dept Internal Med, Ankara, Turkey

[3] Gulhane Mil Med Acad, Dept Med Biochem, Ankara, Turkey

[4] Gulhane Mil Med Acad, Dept Physiol, Ankara, Turkey

[5] Gulhane Mil Med Acad, Dept Pathol, Ankara, Turkey

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2011年 / 71卷 / 03期

关键词：

Acute distal colitis; hyperbaric oxygen therapy; neopterin; ozone therapy; oxidative stress; HYDROGEN-PEROXIDE; NEOPTERIN; EFFICACY; MARKER; PATHOGENESIS; MECHANISMS; INFECTION; RELEASE; DISEASE; BALANCE;

D O I：

10.3109/00365513.2010.548875

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Objectives. Previous studies have shown that hyperbaric oxygen (HBO) is effective in reducing the severity of acute distal colitis (ADC). Ozone therapy (OT) reduces inflammation in several pathological conditions. We aimed to compare the effects of HBO therapy and OT in an experimental ADC rat model. Materials and methods. Forty rats were randomly divided into four groups: Sham, ADC, ADC + HBO, and ADC + OT. Rats in the sham group were given isotonic saline. In the remaining groups, ADC was created by intracolonic administration of 4% acetic acid. No treatment was given to the ADC group. The rats in the ADC + HBO and ADC + OT groups were given HBO and ozone treatments, respectively. The administration of acetic acid caused an inflammatory response in all animals. Distal colons and blood samples were obtained. Results. The histopathological score was significantly higher in the ADC group compared to the other groups. The histopathological scores in the ADC + HBO and ADC + OT groups were significantly lower compared to the ADC group (both p < 0.001). The most pronounced therapeutic effect was observed in the ADC + OT group. Malondialdehyde and neopterin levels and superoxide dismutase and glutathione peroxidase activities in the ADC group were significantly higher compared to the other groups (p < 0.001). Conclusion. Our data showed that the therapeutic effect of OT is more pronounced than that of HBO therapy. Its possible effect is by means of decreasing inflammation, edema, and oxidative stress. These findings also suggest that it is possible to improve the outcome of ADC by using ozone therapy as an adjuvant therapy.

引用

页码：185 / 192

页数：8

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