Metabolic modulation of inflammation-induced activation of coagulation

被引:51
作者
Levi, Marcel [1 ]
Nieuwdorp, Max [1 ]
van der Poll, Tom [2 ]
Stroes, Erik [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med Internal Med, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, CINIMA, NL-1105 AZ Amsterdam, Netherlands
关键词
coagulation; fibrinolysis; inflammation; cytokines; lipoproteins; cholesterol; triglycerides; glucose; insulin;
D O I
10.1055/s-2008-1066020
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
The bidirectional interaction between coagulation and inflammation, which is relevant in various disease states that are dominated by systemic inflammatory responses, such as severe infection or chronic vascular disease, is modulated by metabolic factors. Changes in lipoprotein metabolism affect the inflammation-induced activation of coagulation, which may have impact on downstream effects, including organ dysfunction and survival. Likewise, glucose and insulin seem to influence inflammation-induced effects on coagulation and fibrinolysis. Hyperglycemia affects inflammation-induced and tissue factor-driven activation of coagulation, whereas hyperinsulinemia modulates the fibrinolytic response. There are indications that this modulatory role of metabolic factors in inflammation and coagulation may also have an impact on clinical outcome in various disease states.
引用
收藏
页码:26 / 32
页数:7
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