Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

被引：145

作者：

Birkenfeld, Joerg ^{[2
]}

Nalbant, Perihan ^{[3
]}

Yoon, Soon-Hee ^{[1
]}

Bokoch, Gary M. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Cell Biol, La Jolla, CA 92037 USA

[2] Direvo Biotech AG, D-50829 Cologne, Germany

[3] Univ Duisburg Essen, Ctr Med Biotechnol, Dept Mol Cell Biol, D-45117 Essen, Germany

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 05期

关键词：

D O I：

10.1016/j.tcb.2008.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Rho guanine nucleotide exchange factor GEF-H1 is uniquely regulated by microtubule binding and is crucial in coupling microtubule dynamics to Rho-GTPase activation in a variety of normal biological situations. Here, we review the roles of GEF-H1 in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. GEF-H1 might also contribute to pathophysiological signaling involved in leukemias, and in cancers associated with mutated p53 tumor suppressor gene, epithelial and endothelial cell dysfunction, infectious disease, and cardiac hypertrophy. We suggest that GEF-H1 could be a novel therapeutic target in multiple human diseases.

引用

页码：210 / 219

页数：10

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