Discovery of an Ebolavirus-Like Filovirus in Europe

被引:282
作者
Negredo, Ana [1 ]
Palacios, Gustavo [2 ,3 ]
Vazquez-Moron, Sonia [1 ]
Gonzalez, Felix [4 ]
Dopazo, Hernan [5 ]
Molero, Francisca [1 ]
Juste, Javier [6 ]
Quetglas, Juan [6 ]
Savji, Nazir [2 ,3 ]
de la Cruz Martinez, Maria [1 ]
Herrera, Jesus Enrique [2 ,3 ]
Pizarro, Manuel [7 ]
Hutchison, Stephen K. [8 ]
Echevarria, Juan E. [1 ]
Lipkin, W. Ian [2 ,3 ]
Tenorio, Antonio [1 ]
机构
[1] ISCIII, Natl Ctr Microbiol, Madrid, Spain
[2] Columbia Univ, Ctr Infect & Immun, New York, NY USA
[3] Columbia Univ, WHO Collaborating Ctr Diagnost Surveillance & Imm, Mailman Sch Publ Hlth, New York, NY USA
[4] Grp Asturiano Estudio & Conservac Murcielagos, Posada De Llanera, Principado De A, Spain
[5] Ctr Invest Principe Felipe, Evolutionary Genom Lab, Valencia, Spain
[6] CSIC, Estn Biol Donana, Evolutionary Biol Unit, E-41080 Seville, Spain
[7] Univ Complutense, Serv Pathol, Vet Teaching Hosp, Sch Vet, E-28040 Madrid, Spain
[8] Roche Life Sci, Branford, CT USA
关键词
MARBURG VIRUSES; GLYCOPROTEIN; BAT; REEMERGENCE; RESERVOIR; PEPTIDE; DISEASE; RNA;
D O I
10.1371/journal.ppat.1002304
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease. Here we report identification in dead insectivorous bats of a genetically distinct filovirus, provisionally named Lloviu virus, after the site of detection, Cueva del Lloviu, in Spain.
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