Nox enzymes and the biology of reactive oxygen

被引：2449

作者：

Lambeth, JD ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 03期

关键词：

D O I：

10.1038/nri1312

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Professional phagocytes generate high levels of reactive oxygen species (ROS) using a superoxide-generating NADPH oxidase as part of their armoury of microbicidal mechanisms. The multicomponent phagocyte oxidase (Phox), which has been well characterized over the past three decades, includes the catalytic subunit gp91phox. Lower levels of ROS are seen in non-phagocytic cells, but are usually thought to be 'accidental' byproducts of aerobic metabolism. The discovery of a family of superoxide-generating homologues of gp91phox has led to the concept that ROS are 'intentionally' generated in these cells with distinctive cellular functions related to innate immunity, signal transduction and modification of the extracellular matrix.

引用

页码：181 / 189

页数：9

共 69 条

[1] ACTIVATION OF THE NADPH OXIDASE INVOLVES THE SMALL GTP-BINDING PROTEIN P21RAC1 [J].

ABO, A ;

PICK, E ;

HALL, A ;

TOTTY, N ;

TEAHAN, CG ;

SEGAL, AW .

NATURE, 1991, 353 (6345) :668-670

[2] Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation [J].

Ago, T ;

Kuribayashi, F ;

Hiroaki, H ;

Takeya, R ;

Ito, T ;

Kohda, D ;

Sumimoto, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) :4474-4479

[3] Reactive oxygen generated by Nox1 triggers the angiogenic switch [J].

Arbiser, JL ;

Petros, J ;

Klafter, R ;

Govindajaran, B ;

McLaughlin, ER ;

Brown, LF ;

Cohen, C ;

Moses, M ;

Kilroy, S ;

Arnold, RS ;

Lambeth, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :715-720

[4] Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1 [J].

Arnold, RS ;

Shi, J ;

Murad, E ;

Whalen, AM ;

Sun, CQ ;

Polavarapu, R ;

Parthasarathy, S ;

Petros, JA ;

Lambeth, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) :5550-5555

[5] The neutrophil NADPH oxidase [J].

Babior, BM ;

Lambeth, JD ;

Nauseef, W .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2002, 397 (02) :342-344

[6] Two novel proteins activate superoxide generation by the NADPH oxidase NOX1 [J].

Bánfi, B ;

Clark, RA ;

Steger, K ;

Krause, KH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (06) :3510-3513

[7] A Ca2+-activated NADPH oxidase in testis, spleen, and lymph nodes [J].

Bánfi, B ;

Molnár, G ;

Maturana, A ;

Steger, K ;

Hegedûs, B ;

Demaurex, N ;

Krause, KH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (40) :37594-37601

[8] Role of NADPH oxidases in the control of vascular gene expression [J].

Brandes, RP .

ANTIOXIDANTS & REDOX SIGNALING, 2003, 5 (06) :803-811

[9] NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells [J].

Brar, SS ;

Corbin, Z ;

Kennedy, TP ;

Hemendinger, R ;

Thornton, L ;

Bommarius, B ;

Arnold, RS ;

Whorton, AR ;

Sturrock, AB ;

Huecksteadt, TP ;

Quinn, MT ;

Krenitsky, K ;

Ardie, KG ;

Lambeth, JD ;

Hoidal, JR .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003, 285 (02) :C353-C369

[10] An NAD(P)H oxidase regulates growth and transcription in melanoma cells [J].

Brar, SS ;

Kennedy, TP ;

Sturrock, AB ;

Huecksteadt, TP ;

Quinn, MT ;

Whorton, AR ;

Hoidal, JR .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2002, 282 (06) :C1212-C1224

← 1 2 3 4 5 6 7 →