Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine

被引：35

作者：

Brueckl, WM

Heinze, E

Milsmann, C

Wein, A

Koebnick, C

Jung, A

Croner, RS

Brabletz, T

Günther, K

Kirchner, T

Hahn, EG

Hohenberger, W

Becker, H

Reingruber, B

机构：

[1] Univ Erlangen Nurnberg, Dept Internal Med 1, D-91054 Erlangen, Germany

[2] Univ Gottingen, Dept Surg, D-37075 Gottingen, Germany

[3] German Inst Human Nutr, Dept Stat, D-14558 Bergholz Rehbrucke, Germany

[4] Univ Erlangen Nurnberg, Dept Pathol, D-91054 Erlangen, Germany

[5] Univ Erlangen Nurnberg, Dept Surg, D-91054 Erlangen, Germany

来源：

CANCER LETTERS | 2004年 / 203卷 / 02期

关键词：

adenocarcinoma of the small intestine; microsatlite instability; mismatch repair deficiency; prognosis;

D O I：

10.1016/j.canlet.2003.08.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adenocarcinoma of the small intestine (ACSI) is a rare condition with few studies addressing follow-up and prognosis. Tumors of 35 patients with curative resection of an ACSI were retrospectively analyzed by immunohistochemistry: p53, hMLH1, hMSH2 and hMSH6 and microsatellite instability (MSI): BAT-26, BAX, TGF-beta RII. With a median follow up of 6.1 years, the median cancer-specific survival (CSS) was 36.2 months. Patients who were highly instable (MSI-H) (n = 10) had a CSS of 49.6 months in contrast to patients with stable tumors (23.2 months) (P = 0.010). Additionally, a low tumor stage according to UICC and MSI-H were shown to be independent factors (P = 0.005 and P < 0.001) for an increased survival in multivariate analysis. Therefore, it is suggested that analysis of the MSI status might prove useful in discerning prognosis within cancers of the same stage. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：181 / 190

页数：10

共 48 条

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