The α4β1 integrin in sickle cell disease

被引：12

作者：

Brittain, J. E. ^{[1
]}

Parise, L. V. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Chapel Hill, NC 27599 USA

来源：

TRANSFUSION CLINIQUE ET BIOLOGIQUE | 2008年 / 15卷 / 1-2期

关键词：

alpha 4 beta 1 integrin activation; sickle cell disease; adhesion molecules; vaso-occlusion;

D O I：

10.1016/j.tracli.2008.03.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The alpha 4 beta 1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the alpha 4 beta 1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：19 / 22

页数：4

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