Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies

被引：26

作者：

Garcia-Bates, TatianaM. ^{[1
]}

Lehmann, GenieceM. ^{[2
]}

Simpson-Haidaris, Patricia J. ^{[1
,3
,4
]}

Bernstein, Steven H. ^{[3
,5
]}

Sime, Patricia J. ^{[2
,3
,6
]}

Phipps, Richard P. ^{[1
,2
,3
,6
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA

[2] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA

[3] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA

[4] Univ Rochester, Sch Med & Dent, Dept Pathol & Lab Med, Rochester, NY 14642 USA

[5] Univ Rochester, Sch Med & Dent, Lymphoma Biol Program, James P Wilmot Canc Ctr, Rochester, NY 14642 USA

[6] Univ Rochester, Sch Med & Dent, Lung Biol & Dis Program, Rochester, NY 14642 USA

来源：

PPAR RESEARCH | 2008年 / 2008卷

关键词：

D O I：

10.1155/2008/834612

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPAR gamma is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPAR gamma ligands influence hematological malignant cell growth, differentiation, and survival. Understanding the diverse properties of PPAR gamma ligands is crucial for the development of new therapeutic approaches for hematological malignancies. Copyright (C) 2008 Tatiana M. Garcia-Bates et al.

引用

页数：18

共 218 条

[1] The hinge-helix 1 region of peroxisome proliferator-activated receptor γ1 (PPARγ1) mediates interaction with extracellular signal-regulated kinase 5 and PPARγ1 transcriptional activation:: Involvement in flow-induced PPARγ activation in endothelial cells [J].

Akaike, M ;

Che, WY ;

Marmarosh, NL ;

Ohta, S ;

Osawa, M ;

Ding, B ;

Berk, BC ;

Yan, C ;

Abe, J .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (19) :8691-8704

[2] Human bone marrow megakaryocytes and platelets express PPARγ, and PPARγ agonists blunt platelet release of CD40 ligand and thromboxanes [J].

Akbiyik, F ;

Ray, DM ;

Gettings, KF ;

Blumberg, N ;

Francis, CW ;

Phipps, RP .

BLOOD, 2004, 104 (05) :1361-1368

[3] SUMO in cancer - Wrestlers wanted [J].

Alarcon-Vargas, D ;

Ronai, Z .

CANCER BIOLOGY & THERAPY, 2002, 1 (03) :237-242

[4] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[5]

American Cancer Society, 2007, CANC FACTS FIG

[6]

Asou H, 1999, INT J ONCOL, V15, P1027

[7] Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus [J].

Bajaj, M. ;

Suraamornkul, S. ;

Hardies, L. J. ;

Glass, L. ;

Musi, N. ;

DeFronzo, R. A. .

DIABETOLOGIA, 2007, 50 (08) :1723-1731

[8] Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-gamma (hPPAR gamma) gene [J].

Beamer, BA ;

Negri, C ;

Yen, CJ ;

Gavrilova, O ;

Rumberger, JM ;

Durcan, MJ ;

Yarnall, DP ;

Hawkins, AL ;

Griffin, CA ;

Burns, DK ;

Roth, J ;

Reitman, M ;

Shuldiner, AR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 233 (03) :756-759

[9] PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].

Bouhlel, M. Amine ;

Derudas, Bruno ;

Rigamonti, Elena ;

Dievart, Rebecca ;

Brozek, John ;

Haulon, Stephan ;

Zawadzki, Christophe ;

Jude, Brigitte ;

Torpier, Gerard ;

Marx, Nikolaus ;

Staels, Bart ;

Chinetti-Gbaguidi, Giulia .

CELL METABOLISM, 2007, 6 (02) :137-143

[10] Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat [J].

Braissant, O ;

Foufelle, F ;

Scotto, C ;

Dauca, M ;

Wahli, W .

ENDOCRINOLOGY, 1996, 137 (01) :354-366

← 1 2 3 4 5 6 7 8 9 10 →