Probiotics-supplemented feeding in extremely low-birth-weight infants

被引：96

作者：

Al-Hosni, M. ^{[1
]}

Duenas, M. ^{[2
]}

Hawk, M. ^{[3
]}

Stewart, L. A. ^{[2
]}

Borghese, R. A. ^{[4
]}

Cahoon, M. ^{[5
]}

Atwood, L. ^{[5
]}

Howard, D. ^{[6
]}

Ferrelli, K. ^{[7
]}

Soll, R. ^{[5
,8
]}

机构：

[1] St Louis Univ, Dept Pediat, St Louis, MO 63103 USA

[2] St John Hosp & Med Ctr, Dept Pediat, Detroit, MI USA

[3] Cardinal Glennon Childrens Med Ctr, Neonatal Intens Care Unit, St Louis, MO USA

[4] UC Davis Childrens Hosp, Dept Pediat, Sacramento, CA USA

[5] Vermont Childrens Hosp Fletcher Allen Hlth Care, Dept Pediat, Burlington, VT USA

[6] Univ Vermont, Coll Med, Gen Clin Res Ctr, Burlington, VT USA

[7] Vermont Oxford Network, Clin Trial Unit, Burlington, VT USA

[8] Univ Vermont, Coll Med, Dept Pediat, Burlington, VT USA

来源：

JOURNAL OF PERINATOLOGY | 2012年 / 32卷 / 04期

关键词：

extremely low birth weight; post-menstrual age; probiotics supplementation; necrotizing enterocolitis; very-low birth weight; PREVENT NECROTIZING ENTEROCOLITIS; PRETERM INFANTS; CONTROLLED-TRIAL; DOUBLE-BLIND; BIFIDOBACTERIUM-BREVE; ORAL SUPPLEMENTATION; BARRIER FUNCTION; COLONIZATION; GROWTH; INTERLEUKIN-12;

D O I：

10.1038/jp.2011.51

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: The objective of this trial was to test whether probiotic-supplemented feeding to extremely low-birth-weight (ELBW) infants will improve growth as determined by decreasing the percentage of infants with weight below the 10th percentile at 34 weeks postmenstrual age (PMA). Other important outcome measures, such as improving feeding tolerance determined by tolerating larger volume of feeding per day and reducing antimicrobial treatment days during the first 28 days from the initiation of feeding supplementation were also evaluated. Study Design: We conducted a multicenter randomized controlled double-blinded clinical study. The probiotics-supplementation (PS) group received Ladobadllus rbanmosus GG and Bifidobaderium infantis added to the first enteral feeding and continued once daily with feedings thereafter until discharge or until 34 weeks (PMA). The control (C) group received unsupplemented feedings. Infant weight and feeding volumes were recorded daily during the first 28 days of study period. Weights were also recorded at 34 weeks PMA. Result: A total of 101 infants were enrolled (PS 50 versus C 51). There was no difference between the two groups in the percentage of infants with weight below the 10th percentile at 34 weeks PMA (PS group 58% versus C group 60%, (P value 0.83)) or in the average volume of feeding during 28 days after study entry (PS group 59 ml kg(-1) versus C group 71 ml kg(-1) (P value 0.11)). Calculated growth velocity was higher in the PS group compared with the C group (14.9 versus 12.6 g per day, (P value 0.05)). Incidences of necrotizing enterocolitis (NEC), as well as mortality were similar between the two groups. Conclusion: Although probiotic-supplemented feedings improve growth velocity in ELBW infants, there was no improvement in the percentage of infants with growth delay at 34 weeks PMA. There were no probiotic-related adverse events reported. journal of Perinalology (2012) 32, 253-259; doi:10.1038/jp.2011.51; published online 5 May 2011

引用

页码：253 / 259

页数：7

共 40 条

[1] Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates [J].