STAT3 signaling in immunity

被引：769

作者：

Hillmer, Emily J. ^{[1
]}

Zhang, Huiyuan ^{[1
]}

Li, Haiyan S. ^{[1
]}

Watowich, Stephanie S. ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[2] Univ Texas Houston, Grad Sch Biomed Sci, Houston, TX 77030 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2016年 / 31卷

关键词：

STAT3; Cytokines; Immune system; Inflammation; HYPER-IGE SYNDROME; DENDRITIC CELL-DEVELOPMENT; REGULATORY T-CELLS; COLONY-STIMULATING FACTOR; EPIDERMAL-GROWTH-FACTOR; PHASE RESPONSE FACTOR; HEMATOPOIETIC PROGENITOR CELLS; BLADDER-CARCINOMA ONCOGENE; FOLLICULAR-HELPER-CELLS; GENOME-WIDE ASSOCIATION;

D O I：

10.1016/j.cytogfr.2016.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer. Strikingly, however, either hyperactivation or inactivation of STAT3 results in human disease, indicating tightly regulated STAT3 function is central to health. Here, we attempt to summarize information on the numerous and distinct biological actions of STAT3, and highlight recent discoveries, with a specific focus on STAT3 function in the immune and hematopoietic systems. Our goal is to spur investigation on mechanisms by which aberrant STAT3 function drives human disease and novel approaches that might be used to modulate disease outcome. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1 / 15

页数：15

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