Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging -: art. no. 041202

被引：39

作者：

Hoffman, RM ^{[1
]}

机构：

[1] Anticanc Inc, San Diego, CA 92111 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2005年 / 10卷 / 04期

关键词：

imaging; fluorescence; image acquistion; image recording;

D O I：

10.1117/1.1992485

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The revolution of in vivo cancer biology enabled by fluorescent proteins is described. The high extinction coefficients, quantum yields, and unique spectral properties of fluorescent proteins have been taken advantage of in order to visualize, in real time, the important aspects of cancer in living animals, including tumor cell trafficking, invasion, metastasis, and angiogenesis. Fluorescent proteins enable whole-body imaging of tumors on internal organs. These multicolored proteins have allowed the color-coding of cancer cells growing in vivo with distinction of different cell types, including host from tumor, with single-cell resolution. (C) 2005 Society of Photo-Optical Instrumentation Engineers.

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页数：10

相关论文

共 94 条

[1]

Ahmed F, 2002, CANCER RES, V62, P7166

[2] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].

Al-Mehdi, AB ;

Tozawa, K ;

Fisher, AB ;

Shientag, L ;

Lee, A ;

Muschel, RJ .

NATURE MEDICINE, 2000, 6 (01) :100-102

[3] Hair follicle-derived blood vessels vascularize tumors in skin and are inhibited by doxorubicin [J].

Amoh, Y ;

Li, LN ;

Yang, M ;

Jiang, P ;

Moossa, AR ;

Katsuoka, K ;

Hoffman, RM .

CANCER RESEARCH, 2005, 65 (06) :2337-2343

[4] Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells [J].

Amoh, Y ;

Li, L ;

Yang, M ;

Moossa, AR ;

Katsuoka, K ;

Penman, S ;

Hoffman, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (36) :13291-13295

[5] Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting [J].

Ando, R ;

Mizuno, H ;

Miyawaki, A .

SCIENCE, 2004, 306 (5700) :1370-1373

[6] Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells [J].

Berezovskaya, O ;

Schimmer, AD ;

Glinskii, AB ;

Pinilla, C ;

Hoffman, RM ;

Reed, JC ;

Glinsky, GV .

CANCER RESEARCH, 2005, 65 (06) :2378-2386

[7] Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma [J].

Bobek, V ;

Kolostova, K ;

Pinterov, D ;

Boubelik, M ;

Jiang, P ;

Yang, M ;

Hoffman, RM .

CLINICAL & EXPERIMENTAL METASTASIS, 2004, 21 (08) :705-708

[8] Chronologically-specific metastatic targeting of human pancreatic tumors in orthotopic models [J].

Bouvet, M ;

Yang, M ;

Nardin, S ;

Wang, X ;

Jiang, P ;

Baranov, E ;

Moossa, AR ;

Hoffman, RM .

CLINICAL & EXPERIMENTAL METASTASIS, 2000, 18 (03) :213-218

[9]

Bouvet M, 2002, CANCER RES, V62, P1534

[10] In vivo molecular target assessment of matrix metalloproteinase inhibition [J].

Bremer, C ;

Tung, CH ;

Weissleder, R .

NATURE MEDICINE, 2001, 7 (06) :743-748

← 1 2 3 4 5 6 7 8 9 10 →