A 1,4-disubstituted quinolizidine from a Madagascan mantelline frog (Mantella)

被引：26

作者：

Jain, P

Garraffo, HM

Yeh, HJC

Spande, TF

Daly, JW

Andriamaharavo, NR

Andriantsiferana, M

机构：

[1] NIDDKD, BIOORGAN CHEM LAB, NIH, BETHESDA, MD 20892 USA

[2] UNIV ANTANANARIVO, LAB CHIM ORGAN PROD NAT, ANTANANARIVO 1001, MADAGASCAR

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 12期

关键词：

D O I：

10.1021/np9605100

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A major alkaloid, 217A, in skin extracts of a mantelline frog (Mantella baroni) was isolated by HPLC and the structure defined by H-1-NMR spectral analysis as (1R,4S,10S)- or (1R,4R,10R)-1-methyl-4-(Z)-(1-pent-2-en-4-ynyl) quinolizidine ii). Four other alkaloids-207I (2), 231A (3), 233A (4), and 235E' (5)-detected in frog skin extracts are proposed to be 1,4-disubstituted quinolizidines based on diagnostic mass and FTIR spectra.

引用

页码：1174 / 1178

页数：5

共 18 条

[1]

[Anonymous], 1993, ALKALOIDS CHEM PHARM

[2]

[Anonymous], 1986, ALKALOIDS

[3]

DALY JW, 1977, HELV CHIM ACTA, V60, P1128, DOI 10.1002/hlca.19770600336

[4] DIETARY SOURCE FOR SKIN ALKALOIDS OF POISON FROGS (DENDROBATIDAE) [J].