(+)-(3R)-N-Hydroxy-2-[(S)-ethoxy(4-methoxyphenyl)phosphoryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

被引：3

作者：

Kurokawa, K

Kanehisa, N

Sawa, M

Kondo, H

Kai, Y

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Chem Mat, Suita, Osaka 5650871, Japan

[2] Nippon Organon KK, Div Res & Dev, R&D Labs, Chem Grp,Miyakojima Ku, Osaka 5340016, Japan

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2001年 / 57卷

关键词：

D O I：

10.1107/S1600536801014222

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title compound, C19H23N2O5P, is one of two diastereomers of an arylphosphonamide hydroxamate. The absolute configuration has been determined to establish the relationship between the stereochemistry at the P atom and the activity in inhibition of matrix metalloproteinases.

引用

页码：o906 / o908

页数：3

共 13 条

[1] SIR92 - a program for automatic solution of crystal structures by direct methods [J].

ALTOMARE, A ;

CASCARANO, G ;

GIACOVAZZO, G ;

GUAGLIARDI, A ;

BURLA, MC ;

POLIDORI, G ;

CAMALLI, M .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1994, 27 :435-435

[2]

CLARK IM, 2000, CURR OPIN ANTIINFLAM, V2, P16

[3] ON ENANTIOMORPH-POLARITY ESTIMATION [J].

FLACK, HD .

ACTA CRYSTALLOGRAPHICA SECTION A, 1983, 39 (NOV) :876-881

[4] REVERSAL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS WITH A HYDROXAMATE INHIBITOR OF MATRIX METALLOPROTEASES [J].

GIJBELS, K ;

GALARDY, RE ;

STEINMAN, L .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (06) :2177-2182

[5]

Johnson CK, 1976, ORNL5138 ORTEPII

[6]

*MOL STRUCT CORP, 1999, TEXS VERS 1 10

[7] A SEMI-EMPIRICAL METHOD OF ABSORPTION CORRECTION [J].

NORTH, ACT ;

PHILLIPS, DC ;

MATHEWS, FS .

ACTA CRYSTALLOGRAPHICA SECTION A-CRYSTAL PHYSICS DIFFRACTION THEORETICAL AND GENERAL CRYSTALLOGRAPHY, 1968, A 24 :351-&

[8] Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases [J].

Pikul, S ;

Dunham, KLM ;

Almstead, NG ;

De, B ;

Natchus, MG ;

Anastasio, MV ;

McPhail, SJ ;

Snider, CE ;

Taiwo, YO ;

Chen, LY ;

Dunaway, CM ;

Gu, F ;

Mieling, GE .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (01) :87-94

[9]

Rigaku, 1998, RIG AFC DIFFR CONTR

[10]

SAWA M, 2001, UNPUB J MED CHEM

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