A close family resemblance: the importance of structure in understanding cytochromes P450

被引：95

作者：

Peterson, JA ^{[1
]}

Graham, SE ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75235 USA

来源：

STRUCTURE | 1998年 / 6卷 / 09期

关键词：

D O I：

10.1016/S0969-2126(98)00109-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytochromes P450 comprise a very large superfamily of hemeproteins which generally monooxygenate hydrophobic compounds. P450s appear to have a common conserved structural core, yet are variable in regions involved in substrate recognition and binding, and in redox-partner binding. These differences can be identified by an analysis in which structural alignments and homology models are used to compare the various classes and families of P450s.

引用

页码：1079 / 1085

页数：7

共 28 条

[1] Molecular dynamics study of time-correlated protein domain motions and molecular flexibility: Cytochrome P450BM-3 [J].

Arnold, GE ;

Ornstein, RL .

BIOPHYSICAL JOURNAL, 1997, 73 (03) :1147-1159

[2] Reduced oxy intermediate observed in D251N cytochrome P450(cam) [J].

Benson, DE ;

Suslick, KS ;

Sligar, SG .

BIOCHEMISTRY, 1997, 36 (17) :5104-5107

[3] SUBSTRATE-DEPENDENT COMPETITION OF DIFFERENT P450 ISOZYMES FOR LIMITING NADPH-CYTOCHROME P450 REDUCTASE [J].

CAWLEY, GF ;

BATIE, CJ ;

BACKES, WL .

BIOCHEMISTRY, 1995, 34 (04) :1244-1247

[4] SOLVENT-ACCESSIBLE SURFACES OF PROTEINS AND NUCLEIC-ACIDS [J].

CONNOLLY, ML .

SCIENCE, 1983, 221 (4612) :709-713

[5] STRUCTURE OF CYTOCHROME P450ERYF INVOLVED IN ERYTHROMYCIN BIOSYNTHESIS [J].

CUPPVICKERY, JR ;

POULOS, TL .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (02) :144-153

[6]

GOTOH O, 1992, J BIOL CHEM, V267, P83

[7] An active site substitution, F87V, converts cytochrome p450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase [J].

GrahamLorence, S ;

Truan, G ;

Peterson, JA ;

Falck, JR ;

Wei, SZ ;

Helvig, C ;

Capdevila, JH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (02) :1127-1135

[8] A 3-DIMENSIONAL MODEL OF AROMATASE CYTOCHROME-P450 [J].

GRAHAMLORENCE, S ;

AMARNEH, B ;

WHITE, RE ;

PETERSON, JA ;

SIMPSON, ER .

PROTEIN SCIENCE, 1995, 4 (06) :1065-1080

[9] STRUCTURE AND FUNCTION OF CYTOCHROMES-P450 - A COMPARATIVE-ANALYSIS OF 3 CRYSTAL-STRUCTURES [J].

HASEMANN, CA ;

KURUMBAIL, RG ;

BODDUPALLI, SS ;

PETERSON, JA ;

DEISENHOFER, J .

STRUCTURE, 1995, 3 (01) :41-62

[10] CRYSTAL-STRUCTURE AND REFINEMENT OF CYTOCHROME P450(TERP) AT 2-CENTER-DOT-3 ANGSTROM RESOLUTION [J].

HASEMANN, CA ;

RAVICHANDRAN, KG ;

PETERSON, JA ;

DEISENHOFER, J .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 236 (04) :1169-1185

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