Synthesis of conjugatable bisphosphonates for molecular imaging of large animals

被引：68

作者：

Bhushan, Kumar R.

Tanaka, Eiichi

Frangioni, John V.

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dep Med, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 42期

关键词：

bisphosphonates; cancer; fluorescent probes; imaging agents; microcalcification;

D O I：

10.1002/anie.200701216

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) No fly in this oinkment: A targeted contrast agent allows real-time visualization of normal bones and hydroxyapatite crystals found in breast-cancer microcalcifications. Synthesis of the agent involves conjugation of a near-infrared fluorophore to methylester-protected Pamidronate derivatives. Large-animal surgical models validate the effectiveness of the agent. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7969 / 7971

页数：3

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