Bradykinin excretion is increased in severely hyperglycemic streptozotocin-diabetic rats

被引：12

作者：

Tschope, C

Gavriluk, V

Reinecke, A

Seidl, U

Riester, U

Hilgenfeldt, U

Ritz, E

Unger, T

机构：

[1] GERMAN INST HIGH BLOOD PRESSURE RES,D-24105 KIEL,GERMANY

[2] UNIV HEIDELBERG,DEPT PHARMACOL,D-69120 HEIDELBERG,GERMANY

[3] UNIV HEIDELBERG,DEPT NEPHROL,D-69115 HEIDELBERG,GERMANY

来源：

IMMUNOPHARMACOLOGY | 1996年 / 33卷 / 1-3期

关键词：

bradykinin; kallikrein; prekallikrein; streptozotocin; diabetic nephropathy; glomerular hypertension;

D O I：

10.1016/0162-3109(96)00094-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The renal kallikrein-kinin system (KKS) was studied in pair-fed streptozotocin (STZ)-induced diabetic rats and compared with age-matched controls. Twelve weeks after STZ injection, rats were normotensive, showed hyperglycemia, proteinuria, polydipsia and reduced glomerular filtration rate (GFR) and body weight. The activities of urinary prekallikrein (PRLK) and kallikrein (KLK) were reduced accompanied by an up to 3-fold increase of bradykinin (BK) excretion compared to controls. The increased BK excretion suggests that the renal KKS in STZ-diabetes is activated and that the reduction in urinary PKLK and KLK activity may be due to an increased consumption of these enzymes or to a negative feedback mechanism. The stimulation of the renal KKS in STZ-diabetcs could reflect an attempt of the organism to balance glomerular hypertension.

引用

页码：344 / 348

页数：5

共 21 条

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