Human parainfluenza virus type I (HPIV1) vaccine candidates designed by reverse genetics are attenuated and efficacious in African green monkeys

被引：35

作者：

Bartlett, EJ ^{[1
]}

Amaro-Carambot, E ^{[1
]}

Surman, SR ^{[1
]}

Newman, JT ^{[1
]}

Collins, PL ^{[1
]}

Murphy, BR ^{[1
]}

Skiadopoulos, MH ^{[1
]}

机构：

[1] NIAID, Infect Dis Lab, Resp Viruses Sect, NIH, Bethesda, MD 20892 USA

来源：

VACCINE | 2005年 / 23卷 / 38期

关键词：

human parainfluenza virus; attenuating mutations; vaccine candidates; non-human primate study;

D O I：

10.1016/j.vaccine.2005.04.035

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A set of recombinant, live attenuated human parainfluenza virus type I (rHPIV1) vaccine candidates was evaluated for attenuation, immunogenicity, and protective efficacy in African green monkeys (AGMs). Temperature sensitive (ts) and non-ts attenuating (att) mutations in the P/C and L genes were introduced individually or in various combinations into rHPIV1, including the C-R84G and HNT553A mutations identified in the present work and the C-F170S, L-Y942A, and L-L992C mutations identified previously. The rHPIV1 vaccine candidates exhibited a spectrum of attenuation in AGMs. One genetically and phenotypically stable vaccine candidate, rC(R84G/F170S)L(Y942A/L992C), was attenuated and efficacious in AGMs and is a promising live attenuated intranasal HPIV I vaccine candidate suitable for clinical evaluation. Published by Elsevier Ltd.

引用

页码：4631 / 4646

页数：16

共 73 条

[1] Respiratory tract viral infections in inner-city asthmatic adults
Atmar, RL
Guy, E
Guntupalli, KK
Zimmerman, JL
Bandi, VD
Baxter, BD
Greenberg, SB
[J]. ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (22) : 2453 - 2459
[2] FURTHER CHARACTERIZATION OF COMPLEMENTATION GROUP-B TEMPERATURE-SENSITIVE MUTANT OF RESPIRATORY SYNCYTIAL VIRUS
BELSHE, RB
RICHARDSON, LS
SCHNITZER, TJ
PREVAR, DA
CAMARGO, E
CHANOCK, RM
[J]. JOURNAL OF VIROLOGY, 1977, 24 (01) : 8 - 12
[3] Recovery of human metapneumovirus from cDNA: optimization of growth in vitro and expression of additional genes
Biacchesi, S
Skiadopoulos, MH
Tran, KC
Murphy, BR
Collins, PL
Buchholz, UJ
[J]. VIROLOGY, 2004, 321 (02) : 247 - 259
[4] MEASLES-VIRUS L-PROTEIN EVIDENCES ELEMENTS OF ANCESTRAL RNA-POLYMERASE
BLUMBERG, BM
CROWLEY, JC
SILVERMAN, JI
MENONNA, J
COOK, SD
DOWLING, PC
[J]. VIROLOGY, 1988, 164 (02) : 487 - 497
[5] The sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion
Cadd, T
Garcin, D
Tapparel, C
Itoh, M
Homma, M
Roux, L
Curran, J
Kolakofsky, D
[J]. JOURNAL OF VIROLOGY, 1996, 70 (08) : 5067 - 5074
[6] CHANOCK RM, 2001, FIELDS VIROLOGY, V1, P1341
[7] EVALUATION OF BOVINE, COLD-ADAPTED HUMAN, AND WILD-TYPE HUMAN PARAINFLUENZA TYPE-3 VIRUSES IN ADULT VOLUNTEERS AND IN CHIMPANZEES
CLEMENTS, ML
BELSHE, RB
KING, J
NEWMAN, F
WESTBLOM, TU
TIERNEY, EL
LONDON, WT
MURPHY, BR
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (06) : 1175 - 1182
[8] COELINGH KLV, 1988, J INFECT DIS, V157, P655, DOI DOI 10.1093/INFDIS/157.4.655
[9] Respiratory syncytial virus: Reverse genetics and vaccine strategies
Collins, PL
Murphy, BR
[J]. VIROLOGY, 2002, 296 (02) : 204 - 211
[10] Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population
Cortez, KJ
Erdman, DD
Peret, TCT
Gill, VJ
Childs, R
Barrett, AJ
Bennett, JE
[J]. JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (09) : 1093 - 1097

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