TRAP: how Toll receptors fraternize

被引：18

作者：

Henneke, P ^{[1
]}

Golenbock, DT ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis, Worcester, MA 01655 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 09期

关键词：

D O I：

10.1038/ni0901-828

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although some cellular responses induced by TLRs are abolished in MyD88-deficient mice,TLR4, unlike TLR9, can still induce activation of NF-kappaB and MAPKs. The discovery of a cytoplasmic adapter protein for TLR4, called TRAP, helps explain this phenomenon.

引用

页码：828 / 830

页数：3

共 15 条

[1] Toll-like receptor 2-mediated NF-κB activation requires a RacI-dependent pathway [J].

Arbibe, L ;

Mira, JP ;

Teusch, N ;

Kline, L ;

Guha, M ;

Mackman, N ;

Godowski, PJ ;

Ulevitch, RJ ;

Knaus, UG .

NATURE IMMUNOLOGY, 2000, 1 (06) :533-540

[2] Cooperation of toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein:: Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling [J].

Bulut, Y ;

Faure, E ;

Thomas, L ;

Equils, O ;

Arditi, M .

JOURNAL OF IMMUNOLOGY, 2001, 167 (02) :987-994

[3] Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor [J].

Burns, K ;

Clatworthy, J ;

Martin, L ;

Martinon, F ;

Plumpton, C ;

Maschera, B ;

Lewis, A ;

Ray, K ;

Tschopp, J ;

Volpe, F .

NATURE CELL BIOLOGY, 2000, 2 (06) :346-351

[4] Trojan peptides: the penetratin system for intracellular delivery [J].

Derossi, D ;

Chassaing, G ;

Prochiantz, A .

TRENDS IN CELL BIOLOGY, 1998, 8 (02) :84-87

[5]

FITZGERALD K, 2001, IN PRESS NATURE

[6] Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α [J].

Fruman, DA ;

Snapper, SB ;

Yballe, CM ;

Davidson, L ;

Yu, JY ;

Alt, FW ;

Cantley, LC .

SCIENCE, 1999, 283 (5400) :393-397

[7] A Toll-like receptor recognizes bacterial DNA [J].

Hemmi, H ;

Takeuchi, O ;

Kawai, T ;

Kaisho, T ;

Sato, S ;

Sanjo, H ;

Matsumoto, M ;

Hoshino, K ;

Wagner, H ;

Takeda, K ;

Akira, S .

NATURE, 2000, 408 (6813) :740-745

[8] TIRAP: an adapter molecule in the Toll signaling pathway [J].

Horng, T ;

Barton, GM ;

Medzhitov, R .

NATURE IMMUNOLOGY, 2001, 2 (09) :835-841

[9] Unresponsiveness of MyD88-deficient mice to endotoxin [J].

Kawai, T ;

Adachi, O ;

Ogawa, T ;

Takeda, K ;

Akira, S .

IMMUNITY, 1999, 11 (01) :115-122

[10] Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis [J].

Kobayashi, N ;

Kadono, Y ;

Naito, A ;

Matsumoto, K ;

Yamamoto, T ;

Tanaka, S ;

Inoue, J .

EMBO JOURNAL, 2001, 20 (06) :1271-1280

← 1 2 →